atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Le Ray, Laure Fournier ; Aubry, Alexandra ; Sougakoff, Wladimir ; Revest, Matthieu ; Robert, Jérôme ; Bonnet, Isabelle ; Veziris, Nicolas ; Morel, Florence
• Description:
  We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
• Subjects:
  • Antitubercular Agents
  • Diarylquinolines
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Mycobacterium Tuberculosis
  • Treatment Failure
  • Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 2022; 28(5):1062-1064
• Pubmed ID:
  35447056
• Pubmed Central ID:
  PMC9045433
• Document Type:
  Journal Article
• Genre:
  Letter
• Volume:
  28
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/117299/cdc_117299_DS1.pdf
• File Type:
  [PDF - 847.07 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b1a39da0ad4f6054b6e0205ac100ec4e7ba4c99a7f870c4f11befff9dec8094f