Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2805.212517
Personal Author:
Le Ray, Laure Fournier ; Aubry, Alexandra ; Sougakoff, Wladimir ; Revest, Matthieu ; Robert, Jérôme ; ... More +
Le Ray, Laure Fournier ; Aubry, Alexandra ; Sougakoff, Wladimir ; Revest, Matthieu ; Robert, Jérôme ; Bonnet, Isabelle ; Veziris, Nicolas ; Morel, Florence ; Less -
Description:
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
Subject:
[+]
Antitubercular Agents
Diarylquinolines
Humans
Microbial Sensitivity Tests
Mutation
Mycobacterium Tuberculosis
Treatment Failure
Tuberculosis, Multidrug-Resistant

Source:
Emerg Infect Dis. 2022 ; 28(5):1062-1064;
Pubmed ID:
35447056
Pubmed Central ID:
PMC9045433
Document Type:
Letter ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b1a39da0ad4f6054b6e0205ac100ec4e7ba4c99a7f870c4f11befff9dec8094f
File Type:

Supporting Files

• 	21-2517-F.gif	gif
  	21-2517-F.jpg	jpeg
  	21-2517-Techapp-s1.pdf	pdf
  	21-2517.nxml	xml

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