atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

Le Ray, Laure Fournier; Aubry, Alexandra; Sougakoff, Wladimir; Revest, Matthieu; Robert, Jérôme; Bonnet, Isabelle; Veziris, Nicolas; Morel, Florence

doi:10.3201/eid2805.212517

i

atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

Supporting Files Public Domain

5 2022
By Le Ray, Laure Fournier ; Aubry, Alexandra ; Sougakoff, Wladimir ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Le Ray, Laure Fournier ; Aubry, Alexandra ; Sougakoff, Wladimir ; Revest, Matthieu ; Robert, Jérôme ; Bonnet, Isabelle ; Veziris, Nicolas ; Morel, Florence
Description:

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
Subjects:

Antitubercular Agents Diarylquinolines Humans Microbial Sensitivity Tests Mutation Mycobacterium Tuberculosis Treatment Failure Tuberculosis, Multidrug-Resistant
Source:

Emerg Infect Dis. 2022; 28(5):1062-1064
Pubmed ID:

35447056
Pubmed Central ID:

PMC9045433
Document Type:

Journal Article
Genre:

Letter
Volume:

28
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b1a39da0ad4f6054b6e0205ac100ec4e7ba4c99a7f870c4f11befff9dec8094f
Download URL:

https://stacks.cdc.gov/view/cdc/117299/cdc_117299_DS1.pdf
File Type:

[PDF - 847.07 KB ]

File Language:

English

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