Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Miller, Aaron C. ; Arakkal, Alan T. ; Sewell, Daniel K. ; Segre, Alberto M. ; Pemmaraju, Sriram V. ; Polgreen, Philip M.
• Corporate Authors:
  CDC MInD-Healthcare Group
• Description:
  We evaluated whether hospitalized patients without diagnosed Clostridioides difficile infection (CDI) increased the risk for CDI among their family members after discharge. We used 2001-2017 US insurance claims data to compare monthly CDI incidence between persons in households with and without a family member hospitalized in the previous 60 days. CDI incidence among insurance enrollees exposed to a recently hospitalized family member was 73% greater than enrollees not exposed, and incidence increased with length of hospitalization among family members. We identified a dose-response relationship between total days of within-household hospitalization and CDI incidence rate ratio. Compared with persons whose family members were hospitalized <1 day, the incidence rate ratio increased from 1.30 (95% CI 1.19-1.41) for 1-3 days of hospitalization to 2.45 (95% CI 1.66-3.60) for >30 days of hospitalization. Asymptomatic C. difficile carriers discharged from hospitals could be a major source of community-associated CDI cases.
• Subjects:
  Clostridium Infections Cross Infection Family Hospitalization Humans Risk Factors
• Source:
  Emerg Infect Dis. 2022; 28(5):932-939
• Pubmed ID:
  35447064
• Pubmed Central ID:
  PMC9045444
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  28
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c3fdf18d6995a4281493d1f7472349b3dab225142e8cd54d5946bef7903e63cc
• Download URL:
  https://stacks.cdc.gov/view/cdc/117288/cdc_117288_DS1.pdf
• File Type:
  [PDF - 470.27 KB ]