Micronutrient Supplementation and Pregnancy Outcomes

Details

• Alternative Title:
  JAMA Intern Med
• Personal Author:
  Liu, Jian-meng ; Mei, Zuguo ; Ye, Rongwei ; Serdula, Mary K. ; Ren, Aiguo ; Cogswell, Mary E.
• Description:
  Background:
  
  Beyond perinatal folic acid supplementation, the need for additional prenatal prophylaxis of iron with or without other micronutrients remains unclear. We aim to investigate the maternal and infant health effects of iron plus folic acid and multiple micronutrient supplements vs folic acid alone when provided to pregnant women with no or mild anemia.
  
  Methods:
  
  In this randomized double-blind controlled trial, 18 775 nulliparous pregnant women with mild or no anemia were enrolled from 5 counties of northern China from May 2006 through April 2009. Women were randomly assigned to daily folicacid (400 μg)(control), folic acid–iron (30 mg), or folic acid, iron, and 13 additional vitamins and minerals provided before 20 weeks gestation to delivery. Primary outcome was perinatal mortality. Secondary outcomes included neonatal and infant mortality, preterm delivery, birthweight, birth length, gestational duration, and maternal hemoglobin concentration and anemia.
  
  Results:
  
  A total of 92.7% of women consumed 80% to 100% of supplements as instructed. On average, women consumed 177 supplements. Compared with daily prenatal folic acid, supplementation with iron–folic acid with or without other micronutrients did not affect the rate of perinatal mortality (8.8, 8.7, and 8.3, respectively) per 1000 births, and relative risks (RRs) were 1.00 (95% CI, 0.68–1.46; P=.99) and 0.94 (95% CI, 0.64–1.39; P=.76), respectively. Risk of other adverse maternal and infant outcomes also did not differ, except that RRs for third-trimester maternal anemia were 0.72 (95% CI, 0.63–0.83; P < .001) and 0.71 (95% CI, 0.62–0.82; P < .001), respectively.
  
  Conclusion:
  
  Prenatal iron–folic acid and other micronutrient supplements provided to Chinese women with no or mild anemia prevented later pregnancy anemia beyond any benefit conferred by folic acid alone but did not affect perinatal mortality or other infant outcomes.
  
  Trial Registration:
  
  clinicaltrials.gov Identifier: NCT00133744
  
  
• Subjects:
  Adult Anemia Birth Weight Double-Blind Method Female Folic Acid Humans Infant Infant, Newborn Infant Mortality Iron Micronutrients Perinatal Mortality Pregnancy Pregnancy Complications Pregnancy Outcome Premature Birth Prenatal Nutritional Physiological Phenomena Trace Elements

  More +
• Source:
  JAMA Intern Med. 173(4):276-282
• Pubmed ID:
  23303315
• Pubmed Central ID:
  PMC9069205
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  China
• Volume:
  173
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:25f8ad90f299451d89f086c881f88e4088919b28480b8bcfd8d7fe8c66df775d
• Download URL:
  https://stacks.cdc.gov/view/cdc/117060/cdc_117060_DS1.pdf
• File Type:
  [PDF - 457.90 KB ]