Prevalence and genetic characterization of noroviruses in children with acute gastroenteritis in Senegal, 2007–2010

Details

• Journal Article:
  J Med Virol
• Personal Author:
  Kebe, Ousmane ; Fernandez-Garcia, Maria-Dolores ; Zinsou, Boris-Enock ; Diop, Amadou ; Fall, Amary ; Ndiaye, Ndack ; Vinjé, Jan ; Ndiaye, Kader
• Description:
  Norovirus is the leading cause of sporadic and epidemic acute gastroenteritis (AGE) in children and adults around the world. We investigated the molecular diversity of noroviruses in a pediatric population in Senegal between 2007 and 2010 before the rotavirus vaccine implementation. Stool samples were collected from 599 children under 5 years of age consulting for AGE in a hospital in Dakar. Specimens were screened for noroviruses using the Allplex™ GI-Virus Assay. Positive samples were genotyped after sequencing of conventional reverse transcription-polymerase chain reaction products. Noroviruses were detected in 79 (13.2%) of the children, with GII.4 (64%) and GII.6 (10%) as the most frequently identified genotypes. Our study describes the distribution of genotypes between 2007 and 2010 and should be a baseline for comparison with more contemporary studies. This could help decision-makers on possible choices of norovirus vaccines in the event of future introduction.
• Subjects:
  Adult Caliciviridae Infections Child Child, Preschool Feces Gastroenteritis Genetic Variation Genotype Humans Infant Norovirus Phylogeny Prevalence Senegal

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• Keywords:
  Diarrhea Genotype Diversity GII.4 GII.6
• DOI:
  http://dx.doi.org/10.1002/jmv.27496
• Pubmed ID:
  34854097
• Pubmed Central ID:
  PMC9018583
• Document Type:
  Text ; Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  94
• Issue:
  6
• Citation:
  J Med Virol. 94(6):2640-2644
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:95f0b5fc271e8d0cdad5eb95c32feea8e60e85a3a74388280842cbf54fa85826ccebc200aa9d70d672224f24b42efc0cc9ee3683603e439982aa355f7416f09c
• Download URL:
  https://stacks.cdc.gov/view/cdc/116635/cdc_116635_DS1.pdf
• File Type:
  [PDF - 749.66 KB ]