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Prevalence and genetic characterization of noroviruses in children with acute gastroenteritis in Senegal, 2007–2010
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6 2022
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Source: J Med Virol. 94(6):2640-2644
[PDF-749.66 KB]
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Alternative Title:J Med Virol
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Description:Norovirus is the leading cause of sporadic and epidemic acute gastroenteritis (AGE) in children and adults around the world. We investigated the molecular diversity of noroviruses in a pediatric population in Senegal between 2007 and 2010 before the rotavirus vaccine implementation. Stool samples were collected from 599 children under 5 years of age consulting for AGE in a hospital in Dakar. Specimens were screened for noroviruses using the Allplex™ GI-Virus Assay. Positive samples were genotyped after sequencing of conventional reverse transcription-polymerase chain reaction products. Noroviruses were detected in 79 (13.2%) of the children, with GII.4 (64%) and GII.6 (10%) as the most frequently identified genotypes. Our study describes the distribution of genotypes between 2007 and 2010 and should be a baseline for comparison with more contemporary studies. This could help decision-makers on possible choices of norovirus vaccines in the event of future introduction.
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Pubmed ID:34854097
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Pubmed Central ID:PMC9018583
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Volume:94
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Issue:6
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