Amplification Artifact in SARS-CoV-2 Omicron Sequences Carrying P681R Mutation, New York, USA

Heguy, Adriana; Dimartino, Dacia; Marier, Christian; Zappile, Paul; Guzman, Emily; Duerr, Ralf; Wang, Guiqing; Plitnick, Jonathan; Russell, Alexis; Lamson, Daryl M.; St. George, Kirsten

doi:10.3201/eid2804.220146

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Amplification Artifact in SARS-CoV-2 Omicron Sequences Carrying P681R Mutation, New York, USA

4 2022
By Heguy, Adriana ; Dimartino, Dacia ; Marier, Christian ; ...
http://dx.doi.org/10.3201/eid2804.220146
Source: Emerg Infect Dis. 2022; 28(4):881-883

[PDF-509.56 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Heguy, Adriana ; Dimartino, Dacia ; Marier, Christian ; Zappile, Paul ; Guzman, Emily ; ... More +

Heguy, Adriana ; Dimartino, Dacia ; Marier, Christian ; Zappile, Paul ; Guzman, Emily ; Duerr, Ralf ; Wang, Guiqing ; Plitnick, Jonathan ; Russell, Alexis ; Lamson, Daryl M. ; St. George, Kirsten Less -
Description:

Of 379 severe acute respiratory syndrome coronavirus 2 samples collected in New York, USA, we detected 86 Omicron variant sequences containing Delta variant mutation P681R. Probable explanations were co-infection with 2 viruses or contamination/amplification artifact. Repeated library preparation with fewer cycles showed the P681R calls were artifactual. Unusual mutations should be interpreted with caution.
Subjects:

[+]

Artifacts Covid-19 Humans Mutation Sars-Cov-2
Source:

Emerg Infect Dis. 2022; 28(4):881-883
Pubmed ID:

35130474
Pubmed Central ID:

PMC8962901
Document Type:

Letter
Place as Subject:

New York
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

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urn:sha256:c8b5f17092bd92ade75fc9520430d87d729191d10333228deb8e67d64d3ac675
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https://stacks.cdc.gov/view/cdc/116350/cdc_116350_DS1.pdf
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