Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2804.212334
Personal Author:
Wilson, Tais M. ; Ritter, Jana M. ; Martines, Roosecelis B. ; Bullock, Hannah A. ; Fair, Pamela ; ... More +
Wilson, Tais M. ; Ritter, Jana M. ; Martines, Roosecelis B. ; Bullock, Hannah A. ; Fair, Pamela ; Radford, Kay W. ; Macêdo, Isabel L. ; Sousa, Davi E.R. ; Gonçalves, Alexandra A.B. ; Romano, Alessandro P. ; Passsos, Pedro H.O. ; Ramos, Daniel G. ; Costa, Gabriela R.T. ; Cavalcante, Karina R.L.J. ; de Melo, Cristiano B. ; Zaki, Sherif R. ; Castro, Marcio B. Less -
Description:
Human alphaherpesvirus 1 (HuAHV1) causes fatal neurologic infections in captive New World primates. To determine risks for interspecies transmission, we examined data for 13 free-ranging, black-tufted marmosets (Callithrix penicillata) that died of HuAHV1 infection and had been in close contact with humans in anthropized areas in Brazil during 2012-2019. We evaluated pathologic changes in the marmosets, localized virus and antigen, and assessed epidemiologic features. The main clinical findings were neurologic signs, necrotizing meningoencephalitis, and ulcerative glossitis; 1 animal had necrotizing hepatitis. Transmission electron microscopy revealed intranuclear herpetic inclusions, and immunostaining revealed HuAHV1 and herpesvirus particles in neurons, glial cells, tongue mucosal epithelium, and hepatocytes. PCR confirmed HuAHV1 infection. These findings illustrate how disruption of the One Health equilibrium in anthropized environments poses risks for interspecies virus transmission with potential spillover not only from animals to humans but also from humans to free-ranging nonhuman primates or other animals.
Subjects:
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Animals Anthropized Environments Brazil Callithrix Fatal Fatal Human Alphaherpesvirus 1 Infection In Free-Ranging Black-Tufted Marmosets In Anthropized Environments, Brazil, 2012–2019 Histopathology Human Alphaherpesvirus 1 Humans Immunohistochemistry Marmoset One Health Pathology Pcr Research Transmission Electron Microscopy Viruses Zoonoses
Source:
Emerg Infect Dis. 2022; 28(4):802-811
Pubmed ID:
35318916
Pubmed Central ID:
PMC8962904
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:4b445ae0ee060811c7919efe5de94cc4f8f28520a82468600c9aa681fa654be3
Download URL:
https://stacks.cdc.gov/view/cdc/116342/cdc_116342_DS1.pdf
File Type:

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