Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India

Raghwani, Jayna; du Plessis, Louis; McCrone, John T.; Hill, Sarah C.; Parag, Kris V.; Thézé, Julien; Kumar, Dinesh; Puvar, Apurva; Pandit, Ramesh; Pybus, Oliver G.; Fournié, Guillaume; Joshi, Madhvi; Joshi, Chaitanya

doi:10.3201/eid2804.212053

i

Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India

Supporting Files

4 2022
By Raghwani, Jayna ; du Plessis, Louis ; McCrone, John T. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Raghwani, Jayna ; du Plessis, Louis ; McCrone, John T. ; Hill, Sarah C. ; Parag, Kris V. ; Thézé, Julien ; Kumar, Dinesh ; Puvar, Apurva ; Pandit, Ramesh ; Pybus, Oliver G. ; Fournié, Guillaume ; Joshi, Madhvi ; Joshi, Chaitanya
Description:

Limited genomic sampling in many high-incidence countries has impeded studies of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology. Consequently, critical questions remain about the generation and global distribution of virus genetic diversity. We investigated SARS-CoV-2 transmission dynamics in Gujarat, India, during the state's first epidemic wave to shed light on spread of the virus in one of the regions hardest hit by the pandemic. By integrating case data and 434 whole-genome sequences sampled across 20 districts, we reconstructed the epidemic dynamics and spatial spread of SARS-CoV-2 in Gujarat. Our findings indicate global and regional connectivity and population density were major drivers of the Gujarat outbreak. We detected >100 virus lineage introductions, most of which appear to be associated with international travel. Within Gujarat, virus dissemination occurred predominantly from densely populated regions to geographically proximate locations that had low population density, suggesting that urban centers contributed disproportionately to virus spread.
Subjects:

Covid-19 Genome, Viral Genomics Humans Phylogeny Sars-Cov-2
Source:

Emerg Infect Dis. 2022; 28(4):751-758
Pubmed ID:

35203112
Pubmed Central ID:

PMC8962880
Document Type:

Journal Article
Funding:

WT_/Wellcome TrustUnited Kingdom/ ; 220414/Z/20/Z/WT_/Wellcome TrustUnited Kingdom/
Place as Subject:

India
Volume:

28
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7999f77cbbe6154562763b8ee2fdb0874c4fe99821d9aa4ddc90fd9f92c36887
Download URL:

https://stacks.cdc.gov/view/cdc/116336/cdc_116336_DS1.pdf
File Type:

[PDF - 2.15 MB ]

File Language:

English

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