Diminishing Immune Responses against Variants of Concern in Dialysis Patients 4 Months after SARS-CoV-2 mRNA Vaccination

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Dulovic, Alex ; Strengert, Monika ; Ramos, Gema Morillas ; Becker, Matthias ; Griesbaum, Johanna ; Junker, Daniel ; Lürken, Karsten ; Beigel, Andrea ; Wrenger, Eike ; Lonnemann, Gerhard ; Cossmann, Anne ; Stankov, Metodi V. ; Dopfer-Jablonka, Alexandra ; Kaiser, Philipp D. ; Traenkle, Bjoern ; Rothbauer, Ulrich ; Krause, Gérard ; Schneiderhan-Marra, Nicole ; Behrens, Georg M.N.
• Description:
  Patients undergoing chronic hemodialysis were among the first to receive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased risk for severe coronavirus disease and high case-fatality rates. By using a previously reported cohort from Germany of at-risk hemodialysis patients and healthy donors, where antibody responses were examined 3 weeks after the second vaccination, we assessed systemic cellular and humoral immune responses in serum and saliva 4 months after vaccination with the Pfizer-BioNTech BNT162b2 vaccine using an interferon-γ release assay and multiplex-based IgG measurements. We further compared neutralization capacity of vaccination-induced IgG against 4 SARS-CoV-2 variants of concern (Alpha, Beta, Gamma, and Delta) by angiotensin-converting enzyme 2 receptor-binding domain competition assay. Sixteen weeks after second vaccination, compared with 3 weeks after, cellular and humoral responses against the original SARS-CoV-2 isolate and variants of concern were substantially reduced. Some dialysis patients even had no detectable B- or T-cell responses.
• Subjects:
  Antibodies, Viral Bnt162 Vaccine Covid-19 Vaccines Humans Immunity, Humoral Renal Dialysis Rna, Messenger Spike Glycoprotein, Coronavirus Vaccination
• Source:
  Emerg Infect Dis. 2022; 28(4):743-750
• Pubmed ID:
  35203113
• Pubmed Central ID:
  PMC8962909
• Document Type:
  Journal Article
• Volume:
  28
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:19b9d7841988865b4c3f3707b0d1bc2f9ec0ec6cf8e30b50a34e7c07ac22e4f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/116326/cdc_116326_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]