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Immunological assessment of influenza vaccines and immune correlates of protection

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File Language:
English


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  • Alternative Title:
    Expert Rev Vaccines
  • Personal Author:
  • Description:
    Influenza vaccines remain the primary public health tool in reducing the ever-present burden of influenza and its complications. In seeking more immunogenic, more effective and more broadly cross-protective influenza vaccines, the landscape of influenza vaccines is rapidly expanding, both in near-term advances and next-generation vaccine design. Although the first influenza vaccines were licensed over 60 years ago, the hemagglutination-inhibition antibody titer is currently the only universally accepted immune correlate of protection against influenza. However, hemagglutination-inhibition titers appear to be less effective at predicting protection in populations at high risk for severe influenza disease; older adults, young children and those with certain medical conditions. The lack of knowledge and validated methods to measure alternate immune markers of protection against influenza remain a substantial barrier to the development of more immunogenic, broadly cross-reactive and effective influenza vaccines. Here, the authors review the knowledge of immune effectors of protection against influenza and discuss assessment methods for a broader range of immunological parameters that could be considered in the evaluation of traditional or new-generation influenza vaccines.
  • Subjects:
  • Keywords:
  • Source:
    Expert Rev Vaccines. 12(5):519-536
  • Pubmed ID:
    23659300
  • Pubmed Central ID:
    PMC9002926
  • Document Type:
    Journal Article
  • Funding:
    CC999999/ImCDC/Intramural CDC HHSUnited States/
  • Volume:
    12
  • Issue:
    5
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:792a7592f64b0793473eaa2b11ae1217fb09838c58bd6b11776de2e87be998235ec7c8709d72386048740452fd3efea02159640deb9ed86657f79ce023c75cde
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  • File Type:
    Filetype[PDF - 911.33 KB ]
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