Effectiveness of MRNA Vaccination in Preventing COVID-19–associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022

Details

• Personal Author:
  Tenforde, Mark W. ; Self, Wesley H. ; Gaglani, Manjusha ; Ginde, Adit A. ; Douin, David J. ; Talbot, H. Keipp ; Casey, Jonathan D. ; Mohr, Nicholas M. ; Zepeski, Anne ; McNeal, Tresa ; Ghamande, Shekhar ; Gibbs, Kevin W. ; Files, D. Clark ; Hager, David N. ; Shehu, Arber ; Prekker, Matthew E. ; Frosch, Anne E. ; Gong, Michelle N. ; Mohamed, Amira ; Johnson, Nicholas J. ; Srinivasan, Vasisht ; Steingrub, Jay S. ; Peltan, Ithan D. ; Brown, Samuel M. ; Martin, Emily T. ; Monto, Arnold S. ; Khan, Akram ; Hough, Catherine L. ; Busse, Laurence W. ; Duggal, Abhijit ; Wilson, Jennifer G. ; Qadir, Nida ; Chang, Steven Y. ; Mallow, Christopher ; Rivas, Carolina ; Babcock, Hilary M. ; Kwon, Jennie H. ; Exline, Matthew C. ; Botros, Mena ; Lauring, Adam S. ; Shapiro, Nathan I. ; Halasa, Natasha ; Chappell, James D. ; Grijalva, Carlos G. ; Rice, Todd W. ; Jones, Ian D. ; Stubblefield, William B. ; Baughman, Adrienne ; Womack, Kelsey N. ; Rhoads, Jillian P. ; Lindsell, Christopher J. ; Hart, Kimberly W. ; Zhu, Yuwei ; Adams, Katherine ; Surie, Diya ; McMorrow, Meredith L. ; Patel, Manish M.
• Corporate Authors:
  IVY Network. ; CDC COVID-19 Emergency Response Team. ; Vanderbilt University Medical Center, Nashville, Tennessee. ; Baylor Scott & White Health. ; Texas A&M University College of Medicine. ; University of Colorado School of Medicine, Aurora, Colorado ; University of Iowa. ; Wake Forest University Baptist Medical Center. ; Johns Hopkins Hospital. ; Hennepin County Medical Center. ; Montefiore Medical Center and Albert Einstein College of Medicine. ; University of Washington School of Medicine. ; Baystate Medical Center, Springfield, Massachusetts ; Intermountain Medical Center. ; University of Utah. ; University of Michigan School of Public Health.
• Description:
  What is already known about this topic? COVID-19 mRNA vaccines provide protection against COVID-19 hospitalization among adults. However, how well mRNA vaccines protect against the most severe outcomes of COVID-19–related illness, including use of invasive mechanical ventilation (IMV) or death, is uncertain.
  
  What is added by this report? Receiving 2 or 3 doses of an mRNA COVID-19 vaccine was associated with a 90% reduction in risk for COVID-19–associated IMV or death. Protection of 3 mRNA vaccine doses during the period of Omicron predominance was 94%.
  
  What are the implications for public health practice? COVID-19 mRNA vaccines are highly effective in preventing the most severe forms of COVID-19. CDC recommends that all persons eligible for vaccination get vaccinated and stay up to date with COVID-19 vaccination.
  
  Suggested citation for this article: Tenforde MW, Self WH, Gaglani M, et al. Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022. MMWR Morb Mortal Wkly Rep. ePub: 18 March 2022.
  
  mm7112e1.htm?s_cid=mm7112e1_w
  
  mm7112e1-H.pdf
  
  
• Subjects:
  2019-nCoV Vaccine MRNA-1273 BNT162 Vaccine CoronaVirus Infections COVID-19 COVID-19 Vaccines Hospitalization MRNA Vaccines Respiration, Artificial SARS-CoV-2 Vaccination Vaccine Efficacy

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• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Name as Subject:
  Moderna Covid-19 Vaccine ; Pfizer-BioNTech COVID-19 Vaccine
• Place as Subject:
  California ; Colorado ; Florida ; Georgia ; Iowa ; Maryland ; Massachusetts ; Michigan ; Minnesota ; Missouri ; New York ; North Carolina ; Ohio ; Oregon ; Tennessee ; Texas ; Utah ; Washington
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:db7512292d3792fc35f4e7a6f100e152aea3f9ef6b8d163df724a5b9a13f685ad6f8db61a7c7f051df4f5712bd10007d9d5553cc2bc09b41c07b4c2a93cb9a46
• Download URL:
  https://stacks.cdc.gov/view/cdc/115515/cdc_115515_DS1.pdf
• File Type:
  [PDF - 358.01 KB ]