Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Currie, Dustin W. ; Shah, Melisa M. ; Salvatore, Phillip P. ; Ford, Laura ; Whaley, Melissa J. ; Meece, Jennifer ; Ivacic, Lynn ; Thornburg, Natalie J. ; Tamin, Azaibi ; Harcourt, Jennifer L. ; Folster, Jennifer ; Medrzycki, Magdalena ; Jain, Shilpi ; Wong, Phili ; Goffard, Kimberly ; Gieryn, Douglas ; Kahrs, Juliana ; Langolf, Kimberly ; Zochert, Tara ; Hsu, Christopher H. ; Kirking, Hannah L. ; Tate, Jacqueline E.
• Corporate Authors:
  for the CDC COVID-19 Response Epidemiology Field Studies Team1
• Description:
  We assessed the relationship between antigen and reverse transcription PCR (RT-PCR) test positivity and successful virus isolation. We found that antigen test results were more predictive of virus recovery than RT-PCR results. However, virus was isolated from some antigen-negative and RT-PCR‒positive paired specimens, providing support for the Centers for Disease Control and Prevention antigen testing algorithm.
• Subjects:
  Antigens, Viral Covid-19 Humans Polymerase Chain Reaction Reverse Transcription Sars-Cov-2 Sensitivity And Specificity
• Source:
  Emerg Infect Dis. 2022; 28(3):717-720
• Pubmed ID:
  35202532
• Pubmed Central ID:
  PMC8888206
• Document Type:
  Journal Article
• Volume:
  28
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3141f859df0adda9ad47a277105ec7c40477dcc538617cf7c8453935c5d5eb80
• Download URL:
  https://stacks.cdc.gov/view/cdc/115215/cdc_115215_DS1.pdf
• File Type:
  [PDF - 698.86 KB ]