Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta

Reagan-Steiner, Sarah; Bhatnagar, Julu; Martines, Roosecelis B.; Milligan, Nicholas S.; Gisondo, Carly; Williams, Frank B.; Lee, Elizabeth; Estetter, Lindsey; Bullock, Hannah; Goldsmith, Cynthia S.; Fair, Pamela; Hand, Julie; Richardson, Gillian; Woodworth, Kate R.; Oduyebo, Titilope; Galang, Romeo R.; Phillips, Rebecca; Belyaeva, Elizaveta; Yin, Xiao-Ming; Meaney-Delman, Dana; Uyeki, Timothy M.; Roberts, Drucilla J.; Zaki, Sherif R.

doi:10.3201/eid2803.211735

i

Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta

Supporting Files Public Domain

3 2022
By Reagan-Steiner, Sarah ; Bhatnagar, Julu ; Martines, Roosecelis B. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Reagan-Steiner, Sarah ; Bhatnagar, Julu ; Martines, Roosecelis B. ; Milligan, Nicholas S. ; Gisondo, Carly ; Williams, Frank B. ; Lee, Elizabeth ; Estetter, Lindsey ; Bullock, Hannah ; Goldsmith, Cynthia S. ; Fair, Pamela ; Hand, Julie ; Richardson, Gillian ; Woodworth, Kate R. ; Oduyebo, Titilope ; Galang, Romeo R. ; Phillips, Rebecca ; Belyaeva, Elizaveta ; Yin, Xiao-Ming ; Meaney-Delman, Dana ; Uyeki, Timothy M. ; Roberts, Drucilla J. ; Zaki, Sherif R.
Description:

Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death.
Subjects:

Autopsy Covid-19 Female Humans Infant, Newborn Infectious Disease Transmission, Vertical Lung Placenta Pregnancy Pregnancy Complications, Infectious Rna, Viral Sars-Cov-2
Source:

Emerg Infect Dis. 2022; 28(3):510-517
Pubmed ID:

35138244
Pubmed Central ID:

PMC8888232
Document Type:

Journal Article
Volume:

28
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7625699a3e70da7f857a26b06044281a7e1c4b6531567ad72417143613d78ca5
Download URL:

https://stacks.cdc.gov/view/cdc/115214/cdc_115214_DS1.pdf
File Type:

[PDF - 3.61 MB ]

File Language:

English

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