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Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta
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3 2022
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Source: Emerg Infect Dis. 2022; 28(3):510-517
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Alternative Title:Emerg Infect Dis
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Description:Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death.
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Pubmed ID:35138244
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Pubmed Central ID:PMC8888232
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Document Type:
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Volume:28
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Issue:3
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