Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2803.211735
Personal Author:
Reagan-Steiner, Sarah ; Bhatnagar, Julu ; Martines, Roosecelis B. ; Milligan, Nicholas S. ; Gisondo, Carly ; ... More +
Reagan-Steiner, Sarah ; Bhatnagar, Julu ; Martines, Roosecelis B. ; Milligan, Nicholas S. ; Gisondo, Carly ; Williams, Frank B. ; Lee, Elizabeth ; Estetter, Lindsey ; Bullock, Hannah ; Goldsmith, Cynthia S. ; Fair, Pamela ; Hand, Julie ; Richardson, Gillian ; Woodworth, Kate R. ; Oduyebo, Titilope ; Galang, Romeo R. ; Phillips, Rebecca ; Belyaeva, Elizaveta ; Yin, Xiao-Ming ; Meaney-Delman, Dana ; Uyeki, Timothy M. ; Roberts, Drucilla J. ; Zaki, Sherif R. ; Less -
Description:
Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death.
Subject:
[+]
Autopsy
COVID-19
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Lung
Placenta
Pregnancy
Pregnancy Complications, Infectious
RNA, Viral
SARS-CoV-2

Source:
Emerg Infect Dis. 2022 ; 28(3):510-517;
Pubmed ID:
35138244
Pubmed Central ID:
PMC8888232
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:7625699a3e70da7f857a26b06044281a7e1c4b6531567ad72417143613d78ca5
File Type:

Supporting Files

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