Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hounmanou, Yaovi M.G. ; Sit, Brandon ; Fakoya, Bolutife ; Waldor, Matthew K. ; Dalsgaard, Anders
• Description:
  Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non‒O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non‒O1/O139, and their continued surveillance is warranted.
• Subjects:
  Animals Cholera Cholera Toxin Genomics Humans Mice Phylogeny Vibrio Cholerae Vibrio Cholerae O1
• Source:
  Emerg Infect Dis. 2022; 28(3):617-624
• Pubmed ID:
  35202520
• Pubmed Central ID:
  PMC8888207
• Document Type:
  Journal Article
• Funding:
  R01 AI042347/AI/NIAID NIH HHSUnited States/ ; R37 AI042347/AI/NIAID NIH HHSUnited States/
• Volume:
  28
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:19da0e3d500f59c27987f9c087f1110e748fb51dd874c96f7412b95e9753108e
• Download URL:
  https://stacks.cdc.gov/view/cdc/115200/cdc_115200_DS1.pdf
• File Type:
  [PDF - 2.52 MB ]