Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2803.210715
Personal Author:
Hounmanou, Yaovi M.G. ; Sit, Brandon ; Fakoya, Bolutife ; Waldor, Matthew K. ; Dalsgaard, Anders
Hounmanou, Yaovi M.G. ; Sit, Brandon ; Fakoya, Bolutife ; Waldor, Matthew K. ; Dalsgaard, Anders Less -
Description:
Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non‒O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non‒O1/O139, and their continued surveillance is warranted.
Subject:
[+]
Animals
Cholera
Cholera Toxin
Genomics
Humans
Mice
Phylogeny
Vibrio Cholerae
Vibrio Cholerae O1

Source:
Emerg Infect Dis. 2022; 28(3):617-624
Pubmed ID:
35202520
Pubmed Central ID:
PMC8888207
Document Type:
Journal Article
Funding:
R01 AI042347/AI/NIAID NIH HHSUnited States/ ; R37 AI042347/AI/NIAID NIH HHSUnited States/
R01 AI042347/AI/NIAID NIH HHSUnited States/ ; R37 AI042347/AI/NIAID NIH HHSUnited States/ Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:19da0e3d500f59c27987f9c087f1110e748fb51dd874c96f7412b95e9753108e
File Type:

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