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Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141
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3 2022
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Source: Emerg Infect Dis. 2022; 28(3):617-624
[PDF-2.52 MB]
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Alternative Title:Emerg Infect Dis
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Description:Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non‒O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non‒O1/O139, and their continued surveillance is warranted.
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Pubmed ID:35202520
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Pubmed Central ID:PMC8888207
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Volume:28
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Issue:3
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