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Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
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2 10 2022
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Source: Viruses. 2022; 14(2)
[PDF-1.46 MB]
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Alternative Title:Viruses
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Personal Author:
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Description:To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (| L., | Linn. var. nudum Hook. f., | Linn., | Murr., | Bobr., | Bobr. by-products, | L., | (L.) Nyl., and |) from the Qinghai-Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (|, |, |, |, |, |, and |) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom |. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6-125 μg/mL. Two extracts (| by-products and |) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of | and | by-products exhibited different anti-influenza effects. The results suggest that extracts of |, |, |, |, |, |, and | contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
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Pubmed ID:35215953
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Pubmed Central ID:PMC8878895
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Volume:14
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Issue:2
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