Influenza Vaccine Effectiveness Against Influenza A–Associated Emergency Department, Urgent Care, and Hospitalization Encounters Among US Adults, 2022–2023

Tenforde, Mark W.; Weber, Zachary A.; Yang, Duck-Hye; DeSilva, Malini B.; Dascomb, Kristin; Irving, Stephanie A.; Naleway, Allison L.; Gaglani, Manjusha; Fireman, Bruce; Lewis, Ned; Zerbo, Ousseny; Goddard, Kristin; Timbol, Julius; Hansen, John R.; Grisel, Nancy; Arndorfer, Julie; McEvoy, Charlene E.; Essien, Inih J.; Rao, Suchitra; Grannis, Shaun J.; Kharbanda, Anupam B.; Natarajan, Karthik; Ong, Toan C.; Embi, Peter J.; Ball, Sarah W.; Dunne, Margaret M.; Kirshner, Lindsey; Wiegand, Ryan E.; Dickerson, Monica; Patel, Palak; Ray, Caitlin; Flannery, Brendan; Garg, Shikha; Adams, Katherine; Klein, Nicola P.

doi:10.1093/infdis/jiad542

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Influenza Vaccine Effectiveness Against Influenza A–Associated Emergency Department, Urgent Care, and Hospitalization Encounters Among US Adults, 2022–2023

7 25 2024
By Tenforde, Mark W. ; Weber, Zachary A. ; Yang, Duck-Hye ; ...
http://dx.doi.org/10.1093/infdis/jiad542
Source: J Infect Dis. 230(1):141-151

[PDF-745.67 KB]

English

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Details:

Alternative Title:

J Infect Dis
Personal Author:

Tenforde, Mark W. ; Weber, Zachary A. ; Yang, Duck-Hye ; DeSilva, Malini B. ; Dascomb, Kristin ; ... More +

Tenforde, Mark W. ; Weber, Zachary A. ; Yang, Duck-Hye ; DeSilva, Malini B. ; Dascomb, Kristin ; Irving, Stephanie A. ; Naleway, Allison L. ; Gaglani, Manjusha ; Fireman, Bruce ; Lewis, Ned ; Zerbo, Ousseny ; Goddard, Kristin ; Timbol, Julius ; Hansen, John R. ; Grisel, Nancy ; Arndorfer, Julie ; McEvoy, Charlene E. ; Essien, Inih J. ; Rao, Suchitra ; Grannis, Shaun J. ; Kharbanda, Anupam B. ; Natarajan, Karthik ; Ong, Toan C. ; Embi, Peter J. ; Ball, Sarah W. ; Dunne, Margaret M. ; Kirshner, Lindsey ; Wiegand, Ryan E. ; Dickerson, Monica ; Patel, Palak ; Ray, Caitlin ; Flannery, Brendan ; Garg, Shikha ; Adams, Katherine ; Klein, Nicola P. Less -
Description:

Background.

The 2022–2023 United States influenza season had unusually early influenza activity with high hospitalization rates. Vaccine-matched A(H3N2) viruses predominated, with lower levels of A(H1N1)pdm09 activity also observed.

Methods.

Using the test-negative design, we evaluated influenza vaccine effectiveness (VE) during the 2022–2023 season against influenza A–associated emergency department/urgent care (ED/UC) visits and hospitalizations from October 2022 to March 2023 among adults (aged ≥18 years) with acute respiratory illness (ARI). VE was estimated by comparing odds of seasonal influenza vaccination among case-patients (influenza A test positive by molecular assay) and controls (influenza test negative), applying inverse-propensity-to-be-vaccinated weights.

Results.

The analysis included 85 389 ED/UC ARI encounters (17.0% influenza A positive; 37.8% vaccinated overall) and 19 751 hospitalizations (9.5% influenza A positive; 52.8% vaccinated overall). VE against influenza A–associated ED/UC encounters was 44% (95% confidence interval [CI], 40%–47%) overall and 45% and 41% among adults aged 18–64 and ≥65 years, respectively. VE against influenza A–associated hospitalizations was 35% (95% CI, 27%–43%) overall and 23% and 41% among adults aged 18–64 and ≥65 years, respectively.

Conclusions.

VE was moderate during the 2022–2023 influenza season, a season characterized with increased burden of influenza and co-circulation with other respiratory viruses. Vaccination is likely to substantially reduce morbidity, mortality, and strain on healthcare resources.
Subjects:

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Adolescent Adult Aged Ambulatory Care Emergency Service, Hospital Female Hospitalization Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza Vaccines Male Middle Aged Seasons United States Vaccination Vaccine Efficacy Young Adult
Keywords:

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Clinical Outcomes H3N2 Influenza Test-negative Design Vaccine Effectiveness
Source:

J Infect Dis. 230(1):141-151
Pubmed ID:

39052725
Pubmed Central ID:

PMC11306194
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; 75D30120C07986/CC/CDC HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; 75D30120C07986/CC/CDC HHSUnited States/ Less -
Volume:

230
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:f3a028426de42742333701251cb54269166346e2c6ccc7a396529fcdb0f5d8501993d71909e36294f5659d40943f178c7e0151366ebfac5af19e407e20d83811
Download URL:

https://stacks.cdc.gov/view/cdc/159754/cdc_159754_DS1.pdf
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	NIHMS2012677-supplement-Supplementary_Materials.docx	docx

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