Severity of illness by pregnancy status among laboratory-confirmed SARS-CoV-2 infections occurring in reproductive-aged women in Colombia

Details

• Alternative Title:
  Paediatr Perinat Epidemiol
• Personal Author:
  Rozo, Nathaly ; Valencia, Diana ; Newton, Suzanne M. ; Avila, Greace ; Gonzalez, Maritza A. ; Sancken, Christina L. ; Burkel, Veronica K. ; Ellington, Sascha R. ; Gilboa, Suzanne M. ; Rao, Carol Y. ; Azziz-Baumgartner, Eduardo ; Ospina, Martha L. ; Prieto, Franklyn E. ; Tong, Van T.
• Description:
  Background:
  
  Multiple studies have described increased risk of severe coronavirus disease (COVID-19) among pregnant women compared to nonpregnant women. The risk in middle-income countries where the distributions of age groups and preexisting conditions may differ is less known.
  
  Objectives:
  
  To determine whether pregnant women with SARS-CoV-2 infection are at increased risk for severe COVID-19 compared to nonpregnant women in Colombia.
  
  Methods:
  
  We analysed national surveillance data from Colombia, of women aged 15–44 years with laboratory-confirmed infection with SARS-CoV-2 by molecular or antigen testing, from 6 March 2020 to 12 December 2020. An enhanced follow-up of pregnant women with COVID-19 was established to monitor pregnancy and birth outcomes.
  
  Results:
  
  Of 371,363 women aged 15–44 years with laboratory-confirmed SARS-CoV-2 infection, 1.5% (n = 5614) were reported as pregnant; among those, 2610 (46.5%) were considered a complete pregnancy for reporting purposes at the time of analysis. Hospitalisation (23.9%) and death (1.3%) occurred more frequently among pregnant symptomatic women compared to nonpregnant symptomatic women (2.9% and 0.3%, respectively). Compared to nonpregnant symptomatic women, pregnant symptomatic women were at increased risk of hospitalisation (adjusted risk ratio (RR) 2.19, 95% confidence interval (CI) 2.07, 2.32) and death (RR 1.82, 95% CI 1.60, 2.07), after adjusting for age, type of health insurance and presence of certain underlying medical conditions. Among complete pregnancies, 55 (2.1%) were pregnancy losses, 72 (2.8%) resulted in term low birthweight infants and 375 (14.4%) were preterm deliveries.
  
  Conclusions:
  
  Although pregnant women were infrequently reported with laboratory-confirmed SARS-CoV-2 infection, pregnant symptomatic women with COVID-19 were at increased risk for hospitalisation and death compared to nonpregnant symptomatic women. Almost all infections we reported on were third-trimester infections; ongoing follow-up is needed to determine pregnancy outcomes among women infected earlier in pregnancy. Healthcare providers should counsel pregnant women about preventive measures to protect from SARS-CoV-2 infection and when to seek care.
  
  
• Subjects:
  Adult Article Birth Outcomes Colombia Congenital Infection COVID-19 Female Humans Infant, Newborn Patient Acuity Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome SARS-CoV-2

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• Source:
  Paediatr Perinat Epidemiol. 36(4):456-465
• Pubmed ID:
  34467554
• Pubmed Central ID:
  PMC8662193
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  36
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8bbda9dfa8eb44bfeeb4f2b8efaae9e5f3ec5f03c95896a002179c9e38aee339
• Download URL:
  https://stacks.cdc.gov/view/cdc/114965/cdc_114965_DS1.pdf
• File Type:
  [PDF - 564.46 KB ]