Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12808
Personal Author:
Rozo, Nathaly ; Valencia, Diana ; Newton, Suzanne M. ; Avila, Greace ; Gonzalez, Maritza A. ; ... More +
Rozo, Nathaly ; Valencia, Diana ; Newton, Suzanne M. ; Avila, Greace ; Gonzalez, Maritza A. ; Sancken, Christina L. ; Burkel, Veronica K. ; Ellington, Sascha R. ; Gilboa, Suzanne M. ; Rao, Carol Y. ; Azziz-Baumgartner, Eduardo ; Ospina, Martha L. ; Prieto, Franklyn E. ; Tong, Van T. Less -
Description:
Background:

Multiple studies have described increased risk of severe coronavirus disease (COVID-19) among pregnant women compared to nonpregnant women. The risk in middle-income countries where the distributions of age groups and preexisting conditions may differ is less known.

Objectives:

To determine whether pregnant women with SARS-CoV-2 infection are at increased risk for severe COVID-19 compared to nonpregnant women in Colombia.

Methods:

We analysed national surveillance data from Colombia, of women aged 15–44 years with laboratory-confirmed infection with SARS-CoV-2 by molecular or antigen testing, from 6 March 2020 to 12 December 2020. An enhanced follow-up of pregnant women with COVID-19 was established to monitor pregnancy and birth outcomes.

Results:

Of 371,363 women aged 15–44 years with laboratory-confirmed SARS-CoV-2 infection, 1.5% (n = 5614) were reported as pregnant; among those, 2610 (46.5%) were considered a complete pregnancy for reporting purposes at the time of analysis. Hospitalisation (23.9%) and death (1.3%) occurred more frequently among pregnant symptomatic women compared to nonpregnant symptomatic women (2.9% and 0.3%, respectively). Compared to nonpregnant symptomatic women, pregnant symptomatic women were at increased risk of hospitalisation (adjusted risk ratio (RR) 2.19, 95% confidence interval (CI) 2.07, 2.32) and death (RR 1.82, 95% CI 1.60, 2.07), after adjusting for age, type of health insurance and presence of certain underlying medical conditions. Among complete pregnancies, 55 (2.1%) were pregnancy losses, 72 (2.8%) resulted in term low birthweight infants and 375 (14.4%) were preterm deliveries.

Conclusions:

Although pregnant women were infrequently reported with laboratory-confirmed SARS-CoV-2 infection, pregnant symptomatic women with COVID-19 were at increased risk for hospitalisation and death compared to nonpregnant symptomatic women. Almost all infections we reported on were third-trimester infections; ongoing follow-up is needed to determine pregnancy outcomes among women infected earlier in pregnancy. Healthcare providers should counsel pregnant women about preventive measures to protect from SARS-CoV-2 infection and when to seek care.


Subject:
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Adult
COVID-19
Female
Humans
Infant, Newborn
Patient Acuity
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Outcome
SARS-CoV-2

Source:
Paediatr Perinat Epidemiol. 36(4):456-465
Pubmed ID:
34467554
Pubmed Central ID:
PMC8662193
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Place as Subject:
Colombia
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8bbda9dfa8eb44bfeeb4f2b8efaae9e5f3ec5f03c95896a002179c9e38aee339
File Type:

• Supporting Files:
  No Additional Files

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