Occupational Exposure to Ethylene Glycol Monomethyl Ether, Ethylene Glycol Monoethyl Ether, and Their Acetates

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Occupational health risks associated with exposure to ethylene- glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl- ether (110805) (EGEE), ethylene-glycol-monomethyl-ether-acetate (110496) (EGMEA) and ethylene-glycol-monoethyl-ether-acetate (110496) (EGEEA) were examined. The glycol ethers were shown to adversely affect the blood, central nervous and hematopoietic systems, liver and kidneys. Dose related malformations, growth retardation and embryonic death have been demonstrated in the offspring of pregnant animals exposed to airborne concentrations of these chemicals. Testicular atrophy and infertility occurred in male animals exposed to airborne EGME or EGEE at or below their current PELs. NIOSH recommends that exposure to EGME and EGMEA in the workplace be limited to 0.1 parts per million (ppm) of air as a time weighted average for up to 10 hours/day in a 40 hour work week. NIOSH also recommended that exposure to EGEE and EGEEA be limited to the art engineering controls and work practices are to be used to bring about these reductions. EGME, EGEE, and their acetates are readily absorbed through the skin, thus making dermal contact unsafe. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Ether Ethylene Glycols Glycols Liver Nervous System Diseases Occupational Exposure Occupational Health Safety Skin Skin Absorption Urogenital Diseases Urogenital System

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• Keywords:
  NIOSH-Criteria-Document; Ethers; Glycols; Reproductive-system-disorders; Developmental-disorders; Embryotoxicity; Liver-damage; Skin-exposure; Skin-absorption; Testes; Kidney-damage; Nervous-system-disorders
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-119, 1991 Sep; :1-296
• Series:
  NIOSH Numbered Publications
• Subseries:
  Criteria Document
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Standards
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  317 pdf pages
• NIOSHTIC Number:
  nn:00205025
• NTIS Accession Number:
  PB92-167147
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4) ; Ethylene glycol monomethyl ether acetate (CAS RN 110-49-6) ; Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health Guidelines and Recommendations
• Main Document Checksum:
  urn:sha-512:1b8fe84f7e84b7c41cb60d8b9514dfda0f7b26556b19d30b8250964f95b9f3f1f20b3a9c72acc2159cf882524f924d4a9dd34bf983a6ef0568e5eae2f4547cc6
• Download URL:
  https://stacks.cdc.gov/view/cdc/11464/cdc_11464_DS1.pdf
• File Type:
  [PDF - 9.35 MB ]