Clinical and Laboratory Characteristics and Outcome of Illness Caused by Tick-Borne Encephalitis Virus without Central Nervous System Involvement

Bogovič, Petra; Kastrin, Andrej; Lotrič-Furlan, Stanka; Ogrinc, Katarina; Županc, Tatjana Avšič; Korva, Miša; Knap, Nataša; Strle, Franc

doi:10.3201/eid2802.211661

i

Clinical and Laboratory Characteristics and Outcome of Illness Caused by Tick-Borne Encephalitis Virus without Central Nervous System Involvement

Supporting Files Public Domain

2 2022
By Bogovič, Petra ; Kastrin, Andrej ; Lotrič-Furlan, Stanka ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bogovič, Petra ; Kastrin, Andrej ; Lotrič-Furlan, Stanka ; Ogrinc, Katarina ; Županc, Tatjana Avšič ; Korva, Miša ; Knap, Nataša ; Strle, Franc
Description:

Information on febrile illness caused by tick-borne encephalitis virus (TBEV) without central nervous system involvement is limited. We characterized 98 patients who had TBEV RNA in their blood but no central nervous system involvement at the time of evaluation. Median duration of illness was 7 days; 37 (38%) patients were hospitalized. The most frequent findings were malaise or fatigue (98%), fever (97%), headache (86%), and myalgias (54%); common laboratory findings were leukopenia (88%), thrombocytopenia (59%), and abnormal liver test results (63%). During the illness, blood leukocyte counts tended to improve, whereas thrombocytopenia and liver enzymes tended to deteriorate. At the time of positive PCR findings, 0/98 patients had serum IgG TBEV and 7 serum IgM TBEV; all patients later seroconverted. Viral RNA load was higher in patients with more severe illness but did not differ substantially in relation to several other factors. Illness progressed to tick-borne encephalitis in 84% of patients within 18 days after defervescence.
Subjects:

Central Nervous System Clinical And Laboratory Characteristics And Outcome Of Illness Caused By Tick-Borne Encephalitis Virus Without Central Nervous System Involvement Febrile Illness Illness Caused By Tbev Without Cns Involvement Leukopenia Meningitis/Encephalitis Slovenia Synopsis Tbe Tbev Thrombocytopenia Tick-Borne Encephalitis Tick-Borne Encephalitis Virus Vector-Borne Infections Viruses
Source:

Emerg Infect Dis. 2022; 28(2):291-301
Pubmed ID:

35075993
Pubmed Central ID:

PMC8798682
Document Type:

Journal Article
Volume:

28
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:656621dcf4f68a0bdcef76150238aca156c66f4f3b45e6f4cecec98f08c5310b
Download URL:

https://stacks.cdc.gov/view/cdc/114543/cdc_114543_DS1.pdf
File Type:

[PDF - 2.47 MB ]

File Language:

English

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