Waning 2-dose and 3-dose Effectiveness of MRNA Vaccines Against COVID-19–associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variants Predominance — VISION Network, 10 States, August 2021–January 2022

Ferdinands, Jill M.; Rao, Suchitra; Dixon, Brian E.; Mitchell, Patrick K.; DeSilva, Malini B.; Irving, Stephanie A.; Lewis, Ned; Natarajan, Karthik; Stenehjem, Edward; Grannis, Shaun J.; Han, Jungmi; McEvoy, Charlene; Ong, Toan C.; Naleway, Allison L.; Reese, Sarah E.; Embi, Peter J.; Dascomb, Kristin; Klein, Nicola P.; Griggs, Eric P.; Konatham, Deepika; Kharbanda, Anupam B.; Yang, Duck-Hye; Fadel, William F.; Grisel, Nancy; Goddard, Kristin; Patel, Palak; Liao, I-Chia; Birch, Rebecca; Valvi, Nimish R.; Reynolds, Sue; Arndorfer, Julie; Zerbo, Ousseny; Dickerson, Monica; Murthy, Kempapura; Williams, Jeremiah; Bozio, Catherine H.; Blanton, Lenee; Verani, Jennifer R.; Schrag, Stephanie J.; Dalton, Alexandra F.; Wondimu, Mehiret H.; Link-Gelles, Ruth; Azziz-Baumgartner, Eduardo; Barron, Michelle A.; Gaglani, Manjusha; Thompson, Mark G.; Fireman, Bruce

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Waning 2-dose and 3-dose Effectiveness of MRNA Vaccines Against COVID-19–associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variants Predominance — VISION Network, 10 States, August 2021–January 2022

February 11, 2022
By Ferdinands, Jill M. ; Rao, Suchitra ; Dixon, Brian E. ; ...
Source: MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
Series: Weekly Report: Morbidity and Mortality Weekly Report (MMWR)

English

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Details:

Personal Author:

Ferdinands, Jill M. ; Rao, Suchitra ; Dixon, Brian E. ; Mitchell, Patrick K. ; DeSilva, Malini B. ; ... More +

Ferdinands, Jill M. ; Rao, Suchitra ; Dixon, Brian E. ; Mitchell, Patrick K. ; DeSilva, Malini B. ; Irving, Stephanie A. ; Lewis, Ned ; Natarajan, Karthik ; Stenehjem, Edward ; Grannis, Shaun J. ; Han, Jungmi ; McEvoy, Charlene ; Ong, Toan C. ; Naleway, Allison L. ; Reese, Sarah E. ; Embi, Peter J. ; Dascomb, Kristin ; Klein, Nicola P. ; Griggs, Eric P. ; Konatham, Deepika ; Kharbanda, Anupam B. ; Yang, Duck-Hye ; Fadel, William F. ; Grisel, Nancy ; Goddard, Kristin ; Patel, Palak ; Liao, I-Chia ; Birch, Rebecca ; Valvi, Nimish R. ; Reynolds, Sue ; Arndorfer, Julie ; Zerbo, Ousseny ; Dickerson, Monica ; Murthy, Kempapura ; Williams, Jeremiah ; Bozio, Catherine H. ; Blanton, Lenee ; Verani, Jennifer R. ; Schrag, Stephanie J. ; Dalton, Alexandra F. ; Wondimu, Mehiret H. ; Link-Gelles, Ruth ; Azziz-Baumgartner, Eduardo ; Barron, Michelle A. ; Gaglani, Manjusha ; Thompson, Mark G. ; Fireman, Bruce Less -
Corporate Authors:

CDC COVID-19 Emergency Response Team ; University of Colorado Anschutz Medical Campus Dept. of Medicine ; Regenstrief Institute for Health Care‏ Center for Biomedical Informatics ; Indiana University Fairbanks School of Public Health ; Westat ; ... More +

CDC COVID-19 Emergency Response Team ; University of Colorado Anschutz Medical Campus Dept. of Medicine ; Regenstrief Institute for Health Care‏ Center for Biomedical Informatics ; Indiana University Fairbanks School of Public Health ; Westat ; HealthPartners Institute ; Center for Health Research (Kaiser-Permanente Medical Care Program Northwest Region) ; Kaiser Permanente Vaccine Study Center ; Columbia University Dept. of Biomedical Informatics ; New York Presbyterian Hospital ; Intermountain Healthcare, Utah ; Div. of Infectious Diseases and Clinical Epidemiology ; Indiana University School of Medicine ; Vanderbilt University Medical Center, Nashville, Tennessee ; Texas A&M University College of Medicine Baylor Scott & White Health ; Children’s Minnesota (Minneapolis, Minnesota) ; VISION Network Less -
Description:

What is already known about this topic? Protection against COVID-19 after 2 doses of mRNA vaccine wanes, but little is known about durability of protection after 3 doses.

What is added by this report? Vaccine effectiveness (VE) against COVID-19–associated emergency department/urgent care (ED/UC) visits and hospitalizations was higher after the third dose than after the second dose but waned with time since vaccination. During the Omicron-predominant period, VE against COVID-19–associated ED/UC visits and hospitalizations was 87% and 91%, respectively, during the 2 months after a third dose and decreased to 66% and 78% by the fourth month after a third dose. Protection against hospitalizations exceeded that against ED/UC visits.

What are the implications for public health practice? All eligible persons should remain up to date with recommended COVID-19 vaccinations to best protect against COVID-19–associated hospitalizations and ED/UC visits.

Suggested citation for this article: Ferdinands JM, Rao S, Dixon BE, et al. Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022. MMWR Morb Mortal Wkly Rep. ePub: 11 February 2022.

wr/mm7107e2.htm?s_cid=mm7107e2_w

mm7107e2-H.pdf
Subjects:

[+]

2019-nCoV Vaccine MRNA-1273 BNT162 Vaccine CoronaVirus Infections COVID-19 COVID-19 Vaccines Hospitalization Immunization, Secondary RNA, Messenger SARS-CoV-2 Vaccination Vaccine Efficacy
Source:

MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
Series:

Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
ISSN:

0149-2195 (print);1545-861X (digital);
Document Type:

Journal Article
Name as Subject:

Moderna Covid-19 Vaccine ; Pfizer-BioNTech COVID-19 Vaccine

Moderna Covid-19 Vaccine ; Pfizer-BioNTech COVID-19 Vaccine Less -
Place as Subject:

California ; Colorado ; Indiana ; Minnesota ; New York ; ... More +

California ; Colorado ; Indiana ; Minnesota ; New York ; Oregon ; Texas ; Utah ; Washington ; Wisconsin Less -
Pages in Document:

9 pdf pages
Volume:

71
Collection(s):

Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:

[+]

urn:sha-512:41c1fec0637a3289c26f3db7f990725082afa7a3bca790026e30b80ac68c5a56e9f34f722fcc57222b145802b6b4f30f1fd5ed2dd421c4dca08d77e62aba3e9d
Download URL:

https://stacks.cdc.gov/view/cdc/114422/cdc_114422_DS1.pdf
File Type:

[PDF-296.16 KB]

mm7107e2.htm

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