Waning 2-dose and 3-dose Effectiveness of MRNA Vaccines Against COVID-19–associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variants Predominance — VISION Network, 10 States, August 2021–January 2022

Details

• Personal Author:
  Ferdinands, Jill M. ; Rao, Suchitra ; Dixon, Brian E. ; Mitchell, Patrick K. ; DeSilva, Malini B. ; Irving, Stephanie A. ; Lewis, Ned ; Natarajan, Karthik ; Stenehjem, Edward ; Grannis, Shaun J. ; Han, Jungmi ; McEvoy, Charlene ; Ong, Toan C. ; Naleway, Allison L. ; Reese, Sarah E. ; Embi, Peter J. ; Dascomb, Kristin ; Klein, Nicola P. ; Griggs, Eric P. ; Konatham, Deepika ; Kharbanda, Anupam B. ; Yang, Duck-Hye ; Fadel, William F. ; Grisel, Nancy ; Goddard, Kristin ; Patel, Palak ; Liao, I-Chia ; Birch, Rebecca ; Valvi, Nimish R. ; Reynolds, Sue ; Arndorfer, Julie ; Zerbo, Ousseny ; Dickerson, Monica ; Murthy, Kempapura ; Williams, Jeremiah ; Bozio, Catherine H. ; Blanton, Lenee ; Verani, Jennifer R. ; Schrag, Stephanie J. ; Dalton, Alexandra F. ; Wondimu, Mehiret H. ; Link-Gelles, Ruth ; Azziz-Baumgartner, Eduardo ; Barron, Michelle A. ; Gaglani, Manjusha ; Thompson, Mark G. ; Fireman, Bruce
• Corporate Authors:
  CDC COVID-19 Emergency Response Team ; University of Colorado Anschutz Medical Campus Dept. of Medicine ; Regenstrief Institute for Health Care‏ Center for Biomedical Informatics ; Indiana University Fairbanks School of Public Health ; Westat ; HealthPartners Institute ; Center for Health Research (Kaiser-Permanente Medical Care Program Northwest Region) ; Kaiser Permanente Vaccine Study Center ; Columbia University Dept. of Biomedical Informatics ; New York Presbyterian Hospital ; Intermountain Healthcare, Utah ; Div. of Infectious Diseases and Clinical Epidemiology ; Indiana University School of Medicine ; Vanderbilt University Medical Center, Nashville, Tennessee ; Texas A&M University College of Medicine Baylor Scott & White Health ; Children’s Minnesota (Minneapolis, Minnesota) ; VISION Network
• Description:
  What is already known about this topic? Protection against COVID-19 after 2 doses of mRNA vaccine wanes, but little is known about durability of protection after 3 doses.
  
  What is added by this report? Vaccine effectiveness (VE) against COVID-19–associated emergency department/urgent care (ED/UC) visits and hospitalizations was higher after the third dose than after the second dose but waned with time since vaccination. During the Omicron-predominant period, VE against COVID-19–associated ED/UC visits and hospitalizations was 87% and 91%, respectively, during the 2 months after a third dose and decreased to 66% and 78% by the fourth month after a third dose. Protection against hospitalizations exceeded that against ED/UC visits.
  
  What are the implications for public health practice? All eligible persons should remain up to date with recommended COVID-19 vaccinations to best protect against COVID-19–associated hospitalizations and ED/UC visits.
  
  Suggested citation for this article: Ferdinands JM, Rao S, Dixon BE, et al. Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022. MMWR Morb Mortal Wkly Rep. ePub: 11 February 2022.
  
  wr/mm7107e2.htm?s_cid=mm7107e2_w
  
  mm7107e2-H.pdf
  
  
• Subjects:
  2019-nCoV Vaccine MRNA-1273 BNT162 Vaccine CoronaVirus Infections COVID-19 COVID-19 Vaccines Hospitalization Immunization, Secondary RNA, Messenger SARS-CoV-2 Vaccination Vaccine Efficacy

  More +
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Name as Subject:
  Moderna Covid-19 Vaccine ; Pfizer-BioNTech COVID-19 Vaccine
• Place as Subject:
  California ; Colorado ; Indiana ; Minnesota ; New York ; Oregon ; Texas ; Utah ; Washington ; Wisconsin
• Pages in Document:
  9 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:41c1fec0637a3289c26f3db7f990725082afa7a3bca790026e30b80ac68c5a56e9f34f722fcc57222b145802b6b4f30f1fd5ed2dd421c4dca08d77e62aba3e9d
• Download URL:
  https://stacks.cdc.gov/view/cdc/114422/cdc_114422_DS1.pdf
• File Type:
  [PDF - 296.16 KB ]