Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Kaeuffer, Charlotte; Baldacini, Mathieu; Ruge, Tiffany; Ruch, Yvon; Zhu, Yves-Jean; De Cian, Manon; Philouze, Guillaume; Bachellier, Philippe; Denis, Julie; Lefebvre, Nicolas; Schneider, Francis; Hansmann, Yves; Letscher-Bru, Valérie; Herbrecht, Raoul; Sabou, Marcela; Danion, François

doi:10.3201/eid2801.211543

i

Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Supporting Files Public Domain

1 2022
By Kaeuffer, Charlotte ; Baldacini, Mathieu ; Ruge, Tiffany ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Kaeuffer, Charlotte ; Baldacini, Mathieu ; Ruge, Tiffany ; Ruch, Yvon ; Zhu, Yves-Jean ; De Cian, Manon ; Philouze, Guillaume ; Bachellier, Philippe ; Denis, Julie ; Lefebvre, Nicolas ; Schneider, Francis ; Hansmann, Yves ; Letscher-Bru, Valérie ; Herbrecht, Raoul ; Sabou, Marcela ; Danion, François
Description:

Rare fungal pathogens are emerging as agents of invasive fungal infections. We analyzed 13 cases of fungal infections caused by Kazachstania (Arxiozyma) spp. in Strasbourg University Hospital, Strasbourg, France. Among the cases, 4 patients had proven fungal disease (3 cases of invasive fungal disease and 1 mucocutaneous infection) and 9 were colonized by Kazachstania (Arxiozyma) spp. Candida albicans was also isolated from 11 of the 13 patients. None of the patients with proven invasive fungal disease met host criteria, but most had underlying diseases. All strains were identified as K. telluris by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and 3 were confirmed as K. bovina by internal transcribed spacer sequencing. For all tested strains, the MICs for fluconazole were >2 μg/mL. Emergence of this rare fungal infection might be explained by the increasing number of patients with immunocompromised conditions and gastroesophageal diseases.
Subjects:

Antifungal Agents Fluconazole Humans Microbial Sensitivity Tests Mycoses Saccharomycetales Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Source:

Emerg Infect Dis. 2022; 28(1):30-35
Pubmed ID:

34932452
Pubmed Central ID:

PMC8714217
Document Type:

Journal Article
Place as Subject:

France
Volume:

28
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ee4908df3cbaa4b2711f980e9ffe0a94387632b89ef5cc32f2515fa7b80f2e58
Download URL:

https://stacks.cdc.gov/view/cdc/113337/cdc_113337_DS1.pdf
File Type:

[PDF - 1.78 MB ]

File Language:

English

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