High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tanaka, Emi ; Hirai, Yuji ; Wajima, Takeaki ; Ishida, Yu ; Kawamura, Yoshiaki ; Nakaminami, Hidemasa
• Description:
  The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H. haemolyticus from the suction sputum of a 9-year-old patient. The patient had received home medical care with mechanical ventilation for 2 years and had not been exposed to any quinolones for >3 years. The H. haemolyticus strain we isolated, 2019-19, shared biochemical features with H. influenzae. However, whole-genome analysis found this strain was closer to H. haemolyticus. Phylogenetic and mass spectrometry analyses indicated that strain 2019-19 was in the same cluster as H. haemolyticus. Comparison of quinolone resistance-determining regions showed strain 2019-19 possessed various amino acid substitutions, including those associated with quinolone resistance. This report highlights the existence of high-level quinolone-resistant Haemophilus species that have been isolated from both adults and children.
• Subjects:
  Adult Anti-Bacterial Agents Child Haemophilus Haemophilus Infections Humans Phylogeny Quinolones
• Source:
  Emerg Infect Dis. 2022; 28(1):104-110
• Pubmed ID:
  34932443
• Pubmed Central ID:
  PMC8714209
• Document Type:
  Journal Article
• Volume:
  28
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d5a60227ca262d5079b6c2dde4aa6b9b6a6df7e60ff0a76afbb4bd00e017bbc5
• Download URL:
  https://stacks.cdc.gov/view/cdc/113316/cdc_113316_DS1.pdf
• File Type:
  [PDF - 1.66 MB ]