Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines

Adams, Cameron; Jadi, Ramesh; Segovia-Chumbez, Bruno; Daag, Jedas; Ylade, Michelle; Medina, Freddy A.; Sharp, Tyler M.; Munoz-Jordan, Jorge L.; Yoon, In-Kyu; Deen, Jacqueline; Lopez, Anna Lena; de Silva, Aravinda M.; Premkumar, Lakshmanane

doi:10.3201/eid2712.211150

i

Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines

Supporting Files

12 2021
By Adams, Cameron ; Jadi, Ramesh ; Segovia-Chumbez, Bruno ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Adams, Cameron ; Jadi, Ramesh ; Segovia-Chumbez, Bruno ; Daag, Jedas ; Ylade, Michelle ; Medina, Freddy A. ; Sharp, Tyler M. ; Munoz-Jordan, Jorge L. ; Yoon, In-Kyu ; Deen, Jacqueline ; Lopez, Anna Lena ; de Silva, Aravinda M. ; Premkumar, Lakshmanane
Description:

Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used for monitoring DENV transmission is difficult because of antibody cross-reactivity between these closely related flaviviruses. We describe a modified and improved recombinant envelope domain III-based serologic assay for detecting ZIKV type-specific antibodies in regions with endemic DENV transmission. When the assay was used to measure ZIKV seroprevalence in 2017 among children 9-14 years of age living in a region of the Philippines with endemic DENV transmission, we observed a ZIKV seroprevalence of 18%. Investigators should consider using the ZIKV envelope domain III-based assay, which is simple and readily adaptable for use in standard clinical and public health laboratories, to assess ZIKV seroprevalence in areas with endemic DENV transmission.
Subjects:

Antibodies, Viral Child Cross Reactions Dengue Dengue Virus Humans Seroepidemiologic Studies Zika Virus Zika Virus Infection
Source:

Emerg Infect Dis. 2021; 27(12):3073-3081
Pubmed ID:

34808091
Pubmed Central ID:

PMC8632176
Document Type:

Journal Article
Funding:

R21 AI134073/AI/NIAID NIH HHSUnited States/ ; T32 AI007419/AI/NIAID NIH HHSUnited States/ ; U24 AI152170/AI/NIAID NIH HHSUnited States/
Place as Subject:

Philippines
Location:

Asia
Volume:

27
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f4ffa91f57baf45d5cc876166a5e7f08d4e6fd274868f1fd9ec42ac829b83c80
Download URL:

https://stacks.cdc.gov/view/cdc/112615/cdc_112615_DS1.pdf
File Type:

[PDF - 1.35 MB ]

File Language:

English

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