Ischemic Heart and Cerebrovascular Disease Mortality in Uranium Enrichment Workers

Details

• Alternative Title:
  Occup Environ Med
• Personal Author:
  Anderson, JL ; Bertke, SJ ; Yiin, JH ; Kelly-Reif, K ; Daniels, RD
• Description:
  Objective:
  
  Linear and non-linear dose-response relationships between radiation absorbed dose to the lung from internally deposited uranium and external sources and circulatory system disease (CSD) mortality were examined in a cohort of 23,731 male and 5552 female U.S. uranium enrichment workers.
  
  Methods:
  
  Rate ratios (RRs) for categories of lung dose and linear excess relative rates (ERRs) per unit lung dose were estimated to evaluate associations between lung absorbed dose and death from ischemic heart disease (IHD) and cerebrovascular disease (CeVD).
  
  Results:
  
  There was a suggestion of modestly increased IHD risk in workers with internal uranium lung dose above 1 milligray (mGy) (RR = 1.4; 95% CI: 0.76, 2.3) and a statistically significant increased IHD risk with external dose exceeding 150 mGy (RR = 1.3; 95% CI: 1.1, 1.6) compared to the lowest exposed groups. ERRs per mGy were positive for IHD and uranium internal dose and for both outcomes per Gy external dose, although confidence intervals generally included the null.
  
  Conclusions:
  
  Non-linear dose-response models using restricted cubic splines revealed sublinear responses at lower internal doses, suggesting that linear models that are common in radioepidemiological cancer studies may poorly describe the association between uranium internal dose and CSD mortality.
  
  
• Subjects:
  Adult Aged Article Cerebrovascular Disease Cerebrovascular Disorders Dose-response Female Humans Ischemic Heart Disease Male Middle Aged Myocardial Ischemia Occupational Diseases Occupational Exposure Radiation Absorbed Dose Radiation Exposure Risk Factors United States Uranium

  More +
• Source:
  Occup Environ Med. 78(2):105-111
• Pubmed ID:
  32883719
• Pubmed Central ID:
  PMC8647719
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  78
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1de4a3406fee77f6b5027b967059865874887ac5e57ecf012c4c06c47affd072
• Download URL:
  https://stacks.cdc.gov/view/cdc/112439/cdc_112439_DS1.pdf
• File Type:
  [PDF - 440.20 KB ]