Gene-environment interactions between air pollution and biotransformation enzymes and risk of birth defects

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Padula, Amy M. ; Yang, Wei ; Schultz, Kathleen ; Lee, Cecilia ; Lurmann, Fred ; Hammond, S. Katharine ; Shaw, Gary M.
• Description:
  Genetic and environmental factors have been observed to influence risks for birth defects, though few studies have investigated gene-environment interactions. Our aim was to examine the interaction terms of gene variants in biotransformation enzyme pathways and air pollution exposures in relation to risk of several structural birth defects. We evaluated the role of ambient air pollutant exposure (nitrogen dioxide NO| , nitrogen oxide, carbon monoxide, particulate matter <10 PM| and <2.5 PM| microns) during pregnancy and 104 gene variants of biotransformation enzymes from infant bloodspots or buccal cells in a California population-based case-control study in 1997-2006. Cases included cleft lip with or without cleft palate (N = 206), gastroschisis (N = 94), tetralogy of Fallot (N = 69), and dextro-transposition of the great arteries (d-TGA; N = 40) and were compared to 208 nonmalformed controls. Overall, the results were not consistent, though did highlight some associations for further investigation as indicated by Wald chi-square test p value <.1. Increased risk of cleft lip was associated with exposure to high PM| and two CYP gene variants. High PM| and the variant of SLCO1B1 was associated with increased risk of teratology of Fallot. Higher NO| and two gene variants, CYP2A6 and SLC01B1, were associated with increased risk of d-TGA. Results for gastroschisis were inconsistent in direction and across pollutants. These exploratory results suggest that some individuals based on their genetic background may be more susceptible to the adverse effects of air pollution.
• Subjects:
  • Article
  • congenital anomalies
  • cleft lip
  • cleft palate
  • gastroschisis
  • tetralogy of fallot
  • d-TGA
  • gene
  • air pollution
  • gene-environment
  More +
• Source:
  Birth Defects Res. 113(9):676-686
• Pubmed ID:
  33569925
• Pubmed Central ID:
  PMC8651049
• Document Type:
  Journal Article
• Funding:
  P01 ES022849/ES/NIEHS NIH HHSUnited States/ ; P20 ES018173/ES/NIEHS NIH HHSUnited States/ ; R00 ES021470/ES/NIEHS NIH HHSUnited States/ ; U01 DD001226/DD/NCBDD CDC HHSUnited States/ ; U50/CCU913241/CC/CDC HHSUnited States/ ; R01ES031261/ES/NIEHS NIH HHSUnited States/
• Volume:
  113
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/112346/cdc_112346_DS1.pdf
• File Type:
  [PDF - 384.25 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:31fc688b22a64f4f752470a93f34f5d1a86978e869e1b379bcb6b21ebdb7f4de