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Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumor risk in the INTEROCC study
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11 2017
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Source: Occup Environ Med. 74(11):802-809
Details:
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Alternative Title:Occup Environ Med
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Description:Objectives:
In absence of clear evidence regarding possible effects of occupational chemical exposures brain tumor etiology, it is worthwhile to explore the hypothesis that such exposures might act on brain tumor risk in interaction with occupational exposure to extremely low frequency magnetic fields (ELF).
Methods:
INTEROCC is a seven-country (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) population-based case-control study, based on the larger INTERPHONE study. Incident cases of primary glioma and meningioma were ascertained from 2000 to 2004. Job titles were coded into standard international occupational classifications and estimates of ELF and chemical exposures assigned based on job-exposure matrices. Dichotomous indicators of cumulative ELF (≥50th vs <50th percentile, 1–4 year time window) and chemical exposures (ever vs never, 5-year lag) were created. Interaction was assessed on both the additive and multiplicative scales.
Results:
A total of 1,939 glioma cases, 1,822 meningioma cases, and 5,404 controls were included in the analysis, using conditional logistic regression. There was no clear evidence for interactions between ELF and any of the chemical exposures assessed for either glioma or meningioma risk. For glioma, subjects in the low ELF/metal exposed group had a lower risk than would be predicted from marginal effects. Results were similar according to different exposure time windows, cut points of exposure, or in exposed-only analyses.
Conclusions:
There was no clear evidence for interactions between occupational ELF and chemical exposures in relation to glioma or meningioma risk observed. Further research with more refined estimates of occupational exposures is recommended.
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Pubmed ID:28600451
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Pubmed Central ID:PMC8640944
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