Concurrent and Concordant Oral and Genital High-Risk Human Papillomavirus in the U.S.: Results from the National Health and Nutrition Examination Survey

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Custer, James ; Patel, Riddhi ; Delclos, George L. ; DeSantis, Stacia M.
• Description:
  Background:
  
  Oropharyngeal cancers associated with high-risk human papillomavirus (HR-HPV) infection are increasing in the U.S., especially among men. We evaluated prevalence and predictors of concurrent (genital and oral) and concordant (same-type) HR-HPV infections in U.S.
  
  Methods:
  
  We used National Health and Nutrition Examination Survey from 2009–2016. Predictors were assessed via multivariable logistic regression.
  
  Results:
  
  Among 10,334 respondents, 172 (2.1%) had concurrent infections [109 (3.5%) men and 63 (0.76%) women]. Ninety-three (1.0%) had concordant infections [54 (1.6%) men and 39 (0.5%) women]. Predictors of concurrence in men were: no longer married vs. married [2.3 (OR); 1.3–4.9 (95% CI)], living with a partner vs. married [3.0; 1.2–7.5], and having 2–5 lifetime oral sex partners [3.0; 1.2–7.5]. In women they were: no longer married vs. married [3.6; 1.3–10.3], ≥2 recent sex partners [4.6; 1.4–15.6 for 2–5 partners and 3.9; 1.1–14.3 for 6+ partners], and marijuana use [2.2; 1.0–4.5]. The predictor of concordance in men and women was no longer married vs. married [3.5; 1.2–9.9 in men and 3.2; 1.1–9.4 in women].
  
  Conclusions:
  
  Concurrent and concordant HR-HPV infections occur at a high rate, especially among men, and are associated with behavioral factors. This underscores the importance of HPV vaccination, screening, and education in men.
  
  
• Subjects:
  Alphapapillomavirus Female Humans Male Nutrition Surveys Oropharyngeal Neoplasms Papillomaviridae Papillomavirus Infections Prevalence Risk Factors Sexual Behavior Urogenital Diseases

  More +
• Keywords:
  Concordance Concurrence High-risk HPV Infection NHANES
• Source:
  J Infect Dis. 223(8):1400-1409
• Pubmed ID:
  32803235
• Pubmed Central ID:
  PMC8631365
• Document Type:
  Journal Article
• Funding:
  T42 OH008421/OH/NIOSH CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  223
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:584701d8c2fb6fd98e442a7bd19e4d9dd52fc2ee7b8c0a0ebb78bd0df526dd95
• Download URL:
  https://stacks.cdc.gov/view/cdc/112151/cdc_112151_DS1.pdf
• File Type:
  [PDF - 588.46 KB ]