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Cancer mortality update with an exposure response analysis among styrene-exposed workers in the reinforced plastics boatbuilding industry
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7 2018
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Source: Am J Ind Med. 61(7):566-571
[PDF-325.43 KB]
Details:
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Alternative Title:Am J Ind Med
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Description:Background:
There is sparse and inconsistent evidence of an association between styrene exposure and cancer.
Methods:
This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat-building facilities, extending follow-up five years. Standardized mortality ratios (SMR) were calculated using state rates as referent. Cox regression calculated rate ratios per year employed in styrene-exposed exposed jobs.
Results:
No excess deaths from lymphohaematopoietic cancers (LHCs) were observed (SMR: 0.99, 95% CI: 0.74 to 1.30) when compared to the referent population; however, the relative risk increased with duration of employment in internal analyses. Conversely, lung cancer mortality was significantly elevated (SMR: 1.24, 95% CI: 1.08 to 1.41), but there was no evidence of a dose-response relationship.
Conclusion:
We found evidence that occupational exposure to styrene was associated with increased LHC risk, while no such association was observed for lung cancer.
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Pubmed ID:29638005
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Pubmed Central ID:PMC8590871
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Volume:61
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Issue:7
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