Cancer mortality update with an exposure response analysis among styrene-exposed workers in the reinforced plastics boatbuilding industry

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Bertke, Stephen J ; Yiin, James H ; Daniels, Robert D
• Description:
  Background:
  
  There is sparse and inconsistent evidence of an association between styrene exposure and cancer.
  
  Methods:
  
  This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat-building facilities, extending follow-up five years. Standardized mortality ratios (SMR) were calculated using state rates as referent. Cox regression calculated rate ratios per year employed in styrene-exposed exposed jobs.
  
  Results:
  
  No excess deaths from lymphohaematopoietic cancers (LHCs) were observed (SMR: 0.99, 95% CI: 0.74 to 1.30) when compared to the referent population; however, the relative risk increased with duration of employment in internal analyses. Conversely, lung cancer mortality was significantly elevated (SMR: 1.24, 95% CI: 1.08 to 1.41), but there was no evidence of a dose-response relationship.
  
  Conclusion:
  
  We found evidence that occupational exposure to styrene was associated with increased LHC risk, while no such association was observed for lung cancer.
  
  
• Subjects:
  Aged Cohort Studies Employment Female Hematologic Neoplasms Humans Leukemia Lung Neoplasms Lymphoma, Non-Hodgkin Male Manufacturing Industry Middle Aged Multiple Myeloma Neoplasms Occupational Exposure Plastics Proportional Hazards Models Ships Styrene Time Factors

  More +
• Source:
  Am J Ind Med. 61(7):566-571
• Pubmed ID:
  29638005
• Pubmed Central ID:
  PMC8590871
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  Washington
• Volume:
  61
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e907ba9c2fbae4f265cccf006d6815e75f0e08211fc386a25a1f8b71c283ac51
• Download URL:
  https://stacks.cdc.gov/view/cdc/111714/cdc_111714_DS1.pdf
• File Type:
  [PDF - 325.43 KB ]