Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

Xiaoli, Lingzi; Benoliel, Eileen; Peng, Yanhui; Aneke, Janessa; Cassiday, Pamela K.; Kay, Meagan; McKeirnan, Shelly; Duchin, Jeffery S.; Kawakami, Vance; Lindquist, Scott; Acosta, Anna M.; DeBolt, Chas; Tondella, Maria Lucia; Weigand, Michael R.

doi:10.1099/mgen.0.000467

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Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

12 4 2020
By Xiaoli, Lingzi ; Benoliel, Eileen ; Peng, Yanhui ; ...
http://dx.doi.org/10.1099/mgen.0.000467
Source: Microb Genom. 2020; 6(12)

[PDF-412.59 KB]

English

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Details:

Alternative Title:

Microb Genom
Personal Author:

Xiaoli, Lingzi ; Benoliel, Eileen ; Peng, Yanhui ; Aneke, Janessa ; Cassiday, Pamela K. ; ... More +

Xiaoli, Lingzi ; Benoliel, Eileen ; Peng, Yanhui ; Aneke, Janessa ; Cassiday, Pamela K. ; Kay, Meagan ; McKeirnan, Shelly ; Duchin, Jeffery S. ; Kawakami, Vance ; Lindquist, Scott ; Acosta, Anna M. ; DeBolt, Chas ; Tondella, Maria Lucia ; Weigand, Michael R. Less -
Description:

Between July 2018 and May 2019, | was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic | biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available | genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic |.
Subjects:

[+]

Adult Aged Corynebacterium Diphtheriae Corynebacterium Infections Disease Outbreaks Female High-Throughput Nucleotide Sequencing Humans Ill-Housed Persons Male Middle Aged Phylogeny Polymorphism, Single Nucleotide Virulence Factors Whole Genome Sequencing
Source:

Microb Genom. 2020; 6(12)
Pubmed ID:

33275088
Pubmed Central ID:

PMC8116682
Document Type:

Journal Article
Place as Subject:

Washington
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:aed737e48352e38b9f929d70b11f6f924d55cf65d631bb7c21f011d6141b845b
Download URL:

https://stacks.cdc.gov/view/cdc/111626/cdc_111626_DS1.pdf
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