Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

Details

• Alternative Title:
  Microb Genom
• Personal Author:
  Xiaoli, Lingzi ; Benoliel, Eileen ; Peng, Yanhui ; Aneke, Janessa ; Cassiday, Pamela K. ; Kay, Meagan ; McKeirnan, Shelly ; Duchin, Jeffery S. ; Kawakami, Vance ; Lindquist, Scott ; Acosta, Anna M. ; DeBolt, Chas ; Tondella, Maria Lucia ; Weigand, Michael R.
• Description:
  Between July 2018 and May 2019, | was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic | biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available | genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic |.
• Subjects:
  Adult Aged Corynebacterium Diphtheriae Corynebacterium Infections Disease Outbreaks Female High-Throughput Nucleotide Sequencing Humans Ill-Housed Persons Male Middle Aged Phylogeny Polymorphism, Single Nucleotide Virulence Factors Whole Genome Sequencing

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• Source:
  Microb Genom. 2020; 6(12)
• Pubmed ID:
  33275088
• Pubmed Central ID:
  PMC8116682
• Document Type:
  Journal Article
• Place as Subject:
  Washington
• Volume:
  6
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:aed737e48352e38b9f929d70b11f6f924d55cf65d631bb7c21f011d6141b845b
• Download URL:
  https://stacks.cdc.gov/view/cdc/111626/cdc_111626_DS1.pdf
• File Type:
  [PDF - 412.59 KB ]