Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Surasi, Krishna ; Cummings, Kristin J. ; Hanson, Carl ; Morris, Mary Kate ; Salas, Maria ; Seftel, David ; Ortiz, Liza ; Thilakaratne, Ruwan ; Stainken, Cameron ; Wadford, Debra A.
• Description:
  The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%-52.4%), negative percent agreement 100% (95% CI 99.4%-100%), positive predictive value 100% (95% CI 93.5%-100%), and negative predictive value 89.9% (95% CI 87.5%-92.0%). Among 127 rRT-PCR-positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons.
• Subjects:
  Animals Antigens, Viral Coronavirus Infections Covid-19 Disease Outbreaks Horses Humans Sars-Cov-2 Sensitivity And Specificity
• Source:
  Emerg Infect Dis. 27(11):2761-2767
• Pubmed ID:
  34469287
• Pubmed Central ID:
  PMC8544964
• Document Type:
  Journal Article
• Place as Subject:
  California
• Volume:
  27
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:48ae36e69d92ba426652721c49fc7832bf1b12ab1f8b92b898188d11aad5307d
• Download URL:
  https://stacks.cdc.gov/view/cdc/111452/cdc_111452_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]