Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January–April 2021

Hogan, Catherine A.; Jassem, Agatha N.; Sbihi, Hind; Joffres, Yayuk; Tyson, John R.; Noftall, Kyle; Taylor, Marsha; Lee, Tracy; Fjell, Chris; Wilmer, Amanda; Galbraith, John; Romney, Marc G.; Henry, Bonnie; Krajden, Mel; Galanis, Eleni; Prystajecky, Natalie; Hoang, Linda M.N.

doi:10.3201/eid2711.211190

i

Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January–April 2021

Supporting Files Public Domain

11 2021
By Hogan, Catherine A. ; Jassem, Agatha N. ; Sbihi, Hind ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Hogan, Catherine A. ; Jassem, Agatha N. ; Sbihi, Hind ; Joffres, Yayuk ; Tyson, John R. ; Noftall, Kyle ; Taylor, Marsha ; Lee, Tracy ; Fjell, Chris ; Wilmer, Amanda ; Galbraith, John ; Romney, Marc G. ; Henry, Bonnie ; Krajden, Mel ; Galanis, Eleni ; Prystajecky, Natalie ; Hoang, Linda M.N.
Description:

Several severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) emerged in late 2020; lineage B.1.1.7 initially dominated globally. However, lineages B.1.351 and P.1 represent potentially greater risk for transmission and immune escape. In British Columbia, Canada, B.1.1.7 and B.1.351 were first identified in December 2020 and P.1 in February 2021. We combined quantitative PCR and whole-genome sequencing to assess relative contribution of VOCs in nearly 67,000 infections during the first 16 weeks of 2021 in British Columbia. B.1.1.7 accounted for <10% of screened or sequenced specimens early on, increasing to >50% by week 8. P.1 accounted for <10% until week 10, increased rapidly to peak at week 12, and by week 13 codominated within 10% of rates of B.1.1.7. B.1.351 was a minority throughout. This rapid expansion of P.1 but suppression of B.1.351 expands our understanding of population-level VOC patterns and might provide clues to fitness determinants for emerging VOCs.
Subjects:

Coronavirus Infections Covid-19 Humans Real-Time Polymerase Chain Reaction Sars-Cov-2
Source:

Emerg Infect Dis. 27(11):2802-2809
Pubmed ID:

34388358
Pubmed Central ID:

PMC8544957
Document Type:

Journal Article
Place as Subject:

British Columbia, Canada
Volume:

27
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d4def8d4cfc1e5bb231daea45d1c973886a555a1936e48cb16dbb96515c187f0
Download URL:

https://stacks.cdc.gov/view/cdc/111443/cdc_111443_DS1.pdf
File Type:

[PDF - 3.36 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.