Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Immergluck, Katherine ; Gonzalez, Mark D. ; Frediani, Jennifer K. ; Levy, Joshua M. ; Figueroa, Janet ; Wood, Anna ; Rogers, Beverly B. ; O’Neal, Jared ; Elias-Marcellin, Roger ; Suessmith, Allie ; Sullivan, Julie ; Schinazi, Raymond F. ; Babiker, Ahmed ; Piantadosi, Anne ; Vos, Miriam B. ; Martin, Greg S. ; Lam, Wilbur A. ; Waggoner, Jesse J.
• Description:
  Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from antigen-negative persons. Subgenomic RNA in midturbinate swab specimens might be useful for routine diagnostics to identify active virus replication.
• Subjects:
  Coronavirus Infections Covid-19 Diagnostic Tests, Routine Humans Nasopharynx Rna Sars-Cov-2
• Source:
  Emerg Infect Dis. 27(11):2887-2891
• Pubmed ID:
  34424838
• Pubmed Central ID:
  PMC8544990
• Document Type:
  Journal Article
• Funding:
  U54 EB027690/EB/NIBIB NIH HHSUnited States/ ; UL1 TR002378/TR/NCATS NIH HHSUnited States/
• Volume:
  27
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8158857a79c69d0809b9319fe1ba0e7ad7071b7c56ec667eac9271425a0b369b
• Download URL:
  https://stacks.cdc.gov/view/cdc/111440/cdc_111440_DS1.pdf
• File Type:
  [PDF - 1.49 MB ]