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Hemochromatosis, iron-overload related diseases, and pancreatic cancer risk in the Surveillance, Epidemiology, and End Results (SEER)-Medicare
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11 2021
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Source: Cancer Epidemiol Biomarkers Prev. 30(11):2136-2139
[PDF-312.50 KB]
Details:
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Alternative Title:Cancer Epidemiol Biomarkers Prev
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Personal Author:
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Description:Background:
Experimental studies suggest that iron overload might increase pancreatic cancer (PC) risk. We evaluated whether prediagnostic hemochromatosis and iron-overload diseases, including sideroblastic and congenital dyserythropoietic anemias and non-alcoholic related chronic liver disease (NACLD), were associated with PC risk in older adults.
Methods:
We conducted a population-based, case-control study within the United States’ Surveillance, Epidemiology, and End Results Program (SEER)-Medicare linked data. Incident primary PC cases were adults > 66 years. Controls were alive at the time cases were diagnosed and matched to cases (4:1 ratio) by age, sex, and calendar-year. Hemochromatosis, iron-overload anemias, and NACLD were reported 12 or more months before PC diagnosis or control selection using Medicare claims data. Adjusted unconditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) between hemochromatosis, sideroblastic and congenital dyserythropoietic anemias NACLD, and PC.
Results:
Between 1992–2015, 80,074 PC cases and 320,296 controls were identified. Overall, we did not observe statistically significant associations between hemochromatosis, sideroblastic anemia, or congenital dyserythropoietic anemia and PC; however, sideroblastic anemia was associated with later primary PC (OR: 1.30, 95% CI: 1.03–1.64). NACLD was associated with first (OR: 1.10, 95% CI: 1.01–1.19), later (OR: 1.17, 95% CI: 1.02–1.35), and all (OR: 1.12, 95% CI: 1.04–1.20) PC.
Conclusion:
Overall hemochromatosis and iron-overload anemias were not associated with PC, whereas NACLD was associated with increased risk in this large study of older adults.
Impact:
These results partly support the hypothesis that iron-overload diseases increases PC risk.
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Pubmed ID:34479949
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Pubmed Central ID:PMC8568645
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