Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults (EXIT-CJS)

Details

• Alternative Title:
  J Subst Abuse Treat
• Personal Author:
  Waddell, Elizabeth Needham ; Springer, Sandra A. ; Marsch, Lisa A. ; Farabee, David ; Schwartz, Robert P. ; Nyaku, Amesika ; Reeves, Rusty ; Goldfeld, Keith ; McDonald, Ryan D. ; Malone, Mia ; Cheng, Anna ; Saunders, Elizabeth C. ; Monica, Laura ; Gryczynski, Jan ; Bell, Kathleen ; Harding, Kasey ; Violette, Sandra ; Groblewski, Thomas ; Martin, Wendy ; Talon, Kasey ; Beckwith, Nicole ; Suchocki, Andrew ; Torralva, Randy ; Wisdom, Jennifer P. ; Lee, Joshua D.
• Description:
  The EXIT-CJS (N = 1005) multisite open-label randomized controlled trial will compare retention and effectiveness of extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX) to treat opioid use disorder (OUD) among criminal justice system (CJS)-involved adults in six U.S. locales (New Jersey, New York City, Delaware, Oregon, Connecticut, and New Hampshire). With a pragmatic, noninferiority design, this study hypothesizes that XR-B (n = 335) will be noninferior to XR-NTX (n = 335) in retention-in-study-medication treatment (the primary outcome), self-reported opioid use, opioid-positive urine samples, opioid overdose events, and CJS recidivism. In addition, persons with OUD not eligible or interested in the RCT will be recruited into an enhanced treatment as usual arm (n = 335) to examine usual care outcomes in a quasi-experimental observational cohort.
• Keywords:
  Adult Analgesics, Opioid Buprenorphine Criminal Justice Delayed-Action Preparations Humans Injection Injections, Intramuscular Medication Treatment Naltrexone Narcotic Antagonists Opioid-Related Disorders Opioid Use Disorder

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• Source:
  J Subst Abuse Treat. 128:108389
• Pubmed ID:
  33865691
• Pubmed Central ID:
  PMC8384640
• Document Type:
  Journal Article
• Funding:
  R01 CE003008/CE/NCIPC CDC HHSUnited States/ ; P30 DA029926/DA/NIDA NIH HHSUnited States/ ; R01 DA056446/DA/NIDA NIH HHSUnited States/ ; U01 DA047982/DA/NIDA NIH HHSUnited States/ ; K02 DA032322/DA/NIDA NIH HHSUnited States/
• Volume:
  128
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:34ee06fdf690f1cb568fb9815ccf527fbc66ed89640c4be76bb105dd1b45f5eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/111317/cdc_111317_DS1.pdf
• File Type:
  [PDF - 840.81 KB ]