Details:

Alternative Title:
Biol Psychiatry
Publisher's site:
http://dx.doi.org/10.1016/j.biopsych.2021.04.002
Personal Author:
Ames, Jennifer L. ; Ladd-Acosta, Christine ; Fallin, M. Daniele ; Qian, Yinge ; Schieve, Laura A. ; ... More +
Ames, Jennifer L. ; Ladd-Acosta, Christine ; Fallin, M. Daniele ; Qian, Yinge ; Schieve, Laura A. ; DiGuiseppi, Carolyn ; Lee, Li-Ching ; Kasten, Eric P. ; Zhou, Guoli ; Pinto-Martin, Jennifer ; Howerton, Ellen ; Eaton, Christopher L. ; Croen, Lisa A. ; Less -
Description:
Background: The present study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitors (SSRI) use during preconception and pregnancy with risk of neurodevelopmental disorders in offspring. Methods: We used data from the Study to Explore Early Development, a multisite case-control study conducted in the United States among children born between 2003–2011. Final study group classifications of ASD (n=1367), DD (n= 1750), and general population controls (POP)(n=1671) were determined by an in-person standardized developmental assessment. Maternal psychiatric conditions and SSRI use during pregnancy were ascertained from both self-report and medical records. We used logistic regression to evaluate associations of ASD and DD (vs. POP) with maternal psychiatric condition and SSRI treatment in pregnancy. To reduce confounding by indication, we also examined SSRI associations in analyses restricted to mothers with psychiatric conditions during pregnancy. Results: Psychiatric conditions and SSRI use during pregnancy were significantly more common among mothers of children with either ASD or DD than POP controls. Odds of ASD were similarly elevated among mothers with psychiatric conditions who did not use SSRIs during pregnancy (adjusted odds ratio (aOR)=1.81, 95% confidence interval (CI) 1.44–2.27) as in mothers who did use SSRIs (aOR=2.05, 95% CI 1.50–2.80). Among mothers with psychiatric conditions, SSRI use was not significantly associated with ASD in offspring (aOR=1.14, 95% CI 0.8–1.62). Primary findings for DD exhibited similar relationships to those observed with ASD. Conclusions: Maternal psychiatric conditions, but not use of SSRIs during pregnancy, were associated with increased risk of neurodevelopmental disorders in offspring.
Subject:
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Antidepressants
Autism Spectrum Disorder
Case-Control Studies
Child
Female
Humans
Mothers
Neurodevelopmental Disorders
Perinatal Exposure
Pregnancy
Pregnancy Complications
Prenatal Exposure Delayed Effects
Psychiatric Conditions
Serotonin Uptake Inhibitors

Source:
Biol Psychiatry. 90(4):253-262 ;
Pubmed ID:
34116791
Pubmed Central ID:
PMC8504533
Document Type:
Journal Article ;
Funding:
U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; R01 HD087915/HD/NICHD NIH HHSUnited States/ ; ... More +
U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; R01 HD087915/HD/NICHD NIH HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; Less -
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fa0f402cc093df0b333f248fa0a9333849838f1ad8b51abafbcc8f459d822c1a
File Type:

• Supporting Files:
  No Additional Files

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