Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cheung, Patricia C. ; Eisch, A. Robin ; Maleque, Noble ; Polly, Derek M. ; Auld, Sara C. ; Druey, Kirk M.
• Description:
  We report 2 fatal exacerbations of systemic capillary leak syndrome (SCLS), also known as Clarkson disease, associated with coronavirus disease (COVID-19) in the United States. One patient carried an established diagnosis of SCLS and the other sought treatment for new-onset hypotensive shock, hemoconcentration, and anasarca, classic symptoms indicative of an SCLS flare. Both patients had only mild-to-moderate symptoms of COVID-19. This clinical picture suggests that these patients succumbed to complications of SCLS induced by infection with severe acute respiratory syndrome coronavirus 2. Persons with known or suspected SCLS may be at increased risk for developing a disease flare in the setting of mild-to-moderate COVID-19 infection.
• Subjects:
  Capillary Leak Syndrome Coronavirus Infections Covid-19 Humans Sars-Cov-2
• Source:
  Emerg Infect Dis. 27(10):2529-2534
• Pubmed ID:
  34314669
• Pubmed Central ID:
  PMC8462330
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5bcdf9bdcadfd2129e2cac6005ae9c626140b9c22f4523283022a1f500d03f24
• Download URL:
  https://stacks.cdc.gov/view/cdc/110440/cdc_110440_DS1.pdf
• File Type:
  [PDF - 829.42 KB ]