Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Williamson, Brandi N. ; Prescott, Joseph ; Garrido, Jose L. ; Alvarez, Raymond A. ; Feldmann, Heinz ; Barría, Maria I.
• Description:
  Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
• Subjects:
  Animals Antibodies, Monoclonal Cricetinae Hantavirus Hantavirus Infections Humans Mesocricetus
• Source:
  Emerg Infect Dis. 27(10):2707-2710
• Pubmed ID:
  34545791
• Pubmed Central ID:
  PMC8462347
• Document Type:
  Journal Article
• Funding:
  R43 AI138740/AI/NIAID NIH HHSUnited States/
• Place as Subject:
  South America
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:304854bc22efacfbaf5e070c978f9f6de86082ce2bb329c2675c34fdb5396000
• Download URL:
  https://stacks.cdc.gov/view/cdc/110434/cdc_110434_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]