Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Williamson, Brandi N.; Prescott, Joseph; Garrido, Jose L.; Alvarez, Raymond A.; Feldmann, Heinz; Barría, Maria I.

doi:10.3201/eid2710.210735

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Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

10 2021
By Williamson, Brandi N. ; Prescott, Joseph ; Garrido, Jose L. ; ...
http://dx.doi.org/10.3201/eid2710.210735
Source: Emerg Infect Dis. 27(10):2707-2710

[PDF-1.34 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Williamson, Brandi N. ; Prescott, Joseph ; Garrido, Jose L. ; Alvarez, Raymond A. ; Feldmann, Heinz ; ... More +

Williamson, Brandi N. ; Prescott, Joseph ; Garrido, Jose L. ; Alvarez, Raymond A. ; Feldmann, Heinz ; Barría, Maria I. Less -
Description:

Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
Subjects:

[+]

Animals Antibodies, Monoclonal Cricetinae Hantavirus Hantavirus Infections Humans Mesocricetus
Source:

Emerg Infect Dis. 27(10):2707-2710
Pubmed ID:

34545791
Pubmed Central ID:

PMC8462347
Document Type:

Journal Article
Funding:

R43 AI138740/AI/NIAID NIH HHSUnited States/
Place as Subject:

South America
Volume:

27
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:304854bc22efacfbaf5e070c978f9f6de86082ce2bb329c2675c34fdb5396000
Download URL:

https://stacks.cdc.gov/view/cdc/110434/cdc_110434_DS1.pdf
File Type:

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	21-0735-Techapp-s1.pdf	pdf
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