Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bui, Christine H.T. ; Kuok, Denise I.T. ; Yeung, Hin Wo ; Ng, Ka-Chun ; Chu, Daniel K.W. ; ... More +
Bui, Christine H.T. ; Kuok, Denise I.T. ; Yeung, Hin Wo ; Ng, Ka-Chun ; Chu, Daniel K.W. ; Webby, Richard J. ; Nicholls, John M. ; Peiris, J.S. Malik ; Hui, Kenrie P.Y. ; Chan, Michael C.W. Less -
Description:
The numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. They showed differential cellular tropism in human airway organoids; some infected all 4 major epithelial cell types: ciliated cells, club cells, goblet cells, and basal cells. Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. These viruses induced low levels of proinflammatory cytokines/chemokines, which are unlikely to contribute to the pathogenesis of severe disease.
Subjects:
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Animals Birds Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H5N1 Subtype Influenza A Virus, H5N8 Subtype Influenza In Birds Risk Assessment
Source:
Emerg Infect Dis. 27(10):2619-2627
Pubmed ID:
34545790
Pubmed Central ID:
PMC8462306
Document Type:
Journal Article
Funding:
HHSN272201400006C/AI/NIAID NIH HHSUnited States/
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c973628875b6d3f01cc2f880ffc05af870884a7dc769f1b6c4d67feeb982a4f1
Download URL:
https://stacks.cdc.gov/view/cdc/110427/cdc_110427_DS1.pdf
File Type:

Supporting Files

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  	21-0297-Techapp-s1.pdf	pdf
  	21-0297-Techapp-s2.pdf	pdf
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