Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2710.210224
Personal Author:
Fornůsková, Alena ; Hiadlovská, Zuzana ; Macholán, Miloš ; Piálek, Jaroslav ; de Bellocq, Joëlle Goüy
Fornůsková, Alena ; Hiadlovská, Zuzana ; Macholán, Miloš ; Piálek, Jaroslav ; de Bellocq, Joëlle Goüy Less -
Description:
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis; in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic-Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.
Subject:
[+]
Animals
Genome
Lymphocytic Choriomeningitis
Lymphocytic Choriomeningitis Virus
Mice
Phylogeny
Rodent Diseases

Source:
Emerg Infect Dis. 27(10):2638-2647
Pubmed ID:
34545789
Pubmed Central ID:
PMC8462312
Document Type:
Journal Article
Place as Subject:
Czech Republic ; Europe ; Germany
Czech Republic ; Europe ; Germany Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:7d0e67b7687023ace7a750ddd99ca58c4985e560a33aa7e7f28bfc35354cbb92
File Type:

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