Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2710.204818
Personal Author:
Ferrier, Audrey ; Frenois-Veyrat, Gaelle ; Schvoerer, Evelyne ; Henard, Sandrine ; Jarjaval, Fanny ; ... More +
Ferrier, Audrey ; Frenois-Veyrat, Gaelle ; Schvoerer, Evelyne ; Henard, Sandrine ; Jarjaval, Fanny ; Drouet, Isabelle ; Timera, Hawa ; Boutin, Laetitia ; Mosca, Estelle ; Peyrefitte, Christophe ; Ferraris, Olivier Less -
Description:
Cowpox virus (CPXV) has an animal reservoir and is typically transmitted to humans by contact with infected animals. In 2017, CPXV infection of a pregnant woman in France led to the death of her fetus. Fetal death after maternal orthopoxvirus (smallpox) vaccination has been reported; however, this patient had not been vaccinated. Investigation of the patient's domestic animals failed to demonstrate prevalence of CPXV infection among them. The patient's diagnosis was confirmed by identifying CPXV DNA in all fetal and maternal biopsy samples and infectious CPXV in biopsy but not plasma samples. This case of fetal death highlights the risk for complications of orthopoxvirus infection during pregnancy. Among orthopoxviruses, fetal infection has been reported for variola virus and vaccinia virus; our findings suggest that CPXV poses the same threats for infection complications as vaccinia virus.
Subject:
[+]
Animals Cowpox Cowpox Virus Female Fetus Humans Orthopoxvirus
Source:
Emerg Infect Dis. 27(10):2570-2577
Pubmed ID:
34352194
Pubmed Central ID:
PMC8462324
Document Type:
Journal Article
Place as Subject:
France
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:76dad5213a914f4830ee8a4c03f068a6d5545ce8ceb4acc8ae67dc07bce0ca45
Download URL:
https://stacks.cdc.gov/view/cdc/110418/cdc_110418_DS1.pdf
File Type:

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