Fatal Cowpox Virus Infection in Human Fetus, France, 2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ferrier, Audrey ; Frenois-Veyrat, Gaelle ; Schvoerer, Evelyne ; Henard, Sandrine ; Jarjaval, Fanny ; Drouet, Isabelle ; Timera, Hawa ; Boutin, Laetitia ; Mosca, Estelle ; Peyrefitte, Christophe ; Ferraris, Olivier
• Description:
  Cowpox virus (CPXV) has an animal reservoir and is typically transmitted to humans by contact with infected animals. In 2017, CPXV infection of a pregnant woman in France led to the death of her fetus. Fetal death after maternal orthopoxvirus (smallpox) vaccination has been reported; however, this patient had not been vaccinated. Investigation of the patient's domestic animals failed to demonstrate prevalence of CPXV infection among them. The patient's diagnosis was confirmed by identifying CPXV DNA in all fetal and maternal biopsy samples and infectious CPXV in biopsy but not plasma samples. This case of fetal death highlights the risk for complications of orthopoxvirus infection during pregnancy. Among orthopoxviruses, fetal infection has been reported for variola virus and vaccinia virus; our findings suggest that CPXV poses the same threats for infection complications as vaccinia virus.
• Subjects:
  Animals Cowpox Cowpox Virus Female Fetus Humans Orthopoxvirus
• Source:
  Emerg Infect Dis. 27(10):2570-2577
• Pubmed ID:
  34352194
• Pubmed Central ID:
  PMC8462324
• Document Type:
  Journal Article
• Place as Subject:
  France
• Location:
  Europe
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:76dad5213a914f4830ee8a4c03f068a6d5545ce8ceb4acc8ae67dc07bce0ca45
• Download URL:
  https://stacks.cdc.gov/view/cdc/110418/cdc_110418_DS1.pdf
• File Type:
  [PDF - 2.20 MB ]