CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Mortality and cancer incidence among underground uranium miners in the Czech Republic 1977 - 1992
-
8 2019
-
-
Source: Occup Environ Med. 76(8):511-518
[PDF-371.03 KB]
Details:
-
Alternative Title:Occup Environ Med
-
Personal Author:
-
Description:OBJECTIVES:
Uranium miners in Příbram, Czech Republic were exposed to low and moderate levels of radon gas and other hazards. It is unknown whether these hazards increase the risk of mortality or cancer incidence when compared to the general Czech population.
METHODS:
A cohort of 16,434 male underground miners employed underground for at least one year between 1946 and 1976, and alive and residing in the Czech Republic in 1977, were followed for mortality and cancer incidence through 1992. We compared observed deaths and cancer incidence to expectation based on Czech rates. Standardized Mortality Ratios (SMRs), Standardized Incidence Ratios (SIRs) and Causal Mortality Ratios (CMRs) were calculated.
RESULTS:
Underground workers in the Příbram mines had higher rates of death than expected due to all causes (SMR=1.23; 95%CI:1.20,1.27), all cancers (SMR=1.52; 95%CI:1.44,1.60), lung cancer (SMR=2.12; 95%CI:1.96,2.28), and extrathoracic cancer (SMR=1.41; 95%CI:1.15,1.77). Similar excess was observed among cancer incidence analyses, with the addition of stomach cancer (SIR=1.37; 95%CI:1.11,1.63), liver cancer (SIR=1.70; 95%CI:1.16,2.25) and rectal cancer (SIR=1.41; 95%CI:1.16,1.66). The SIR was elevated for all leukemias (SIR=1.51; 95% CI:1.08, 2.07) and for lymphatic and hematopoietic cancers combined (SIR=1.31; 95% CI:1.05,1.61), but results for specific subtypes were imprecise. Deaths due to hazardous mining conditions resulted in 0.33 person-years of life lost per miner.
CONCLUSIONS:
Occupational exposure to the Příbram mines resulted in excess cancers at several sites, including sites previously linked to radon and uranium exposure. Incidence analyses showed relative excess of several additional cancer subtypes.
-
Subjects:
-
Source:
-
Pubmed ID:31167952
-
Pubmed Central ID:PMC8477988
-
Document Type:
-
Funding:
-
Volume:76
-
Issue:8
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
