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EFFECTIVENESS OF MONOVALENT ROTAVIRUS VACCINE AGAINST HOSPITALIZATIONS DUE TO ALL ROTAVIRUS AND EQUINE-LIKE G3P[8] GENOTYPES IN HAITI 2014–2019
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7 22 2021
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Source: Vaccine. 39(32):4458-4462
[PDF-71.44 KB]
Details:
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Alternative Title:Vaccine
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Personal Author:
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Description:Background:
Rotavirus vaccines are effective in preventing severe rotavirus. Haiti introduced 2-dose monovalent (G1P[8]) rotavirus vaccine recommended for infants at 6 and 10 weeks of age in 2014. We calculated the effectiveness of rotavirus vaccine against hospitalization for acute gastroenteritis in Haiti.
Methods:
We enrolled children 6–59 months old admitted May 2014-September 2019 for acute watery diarrhea any sentinel surveillance hospital. Stool was tested for rotavirus using enzyme immunoassay (EIA) and genotyped with multiplex one-step RT-PCR assay and Sanger sequencing for stratification by genotype. We used a case-negative design where cases were children positive for rotavirus and controls were negative for rotavirus. Only children eligible for vaccination were included and a child was considered vaccinated if vaccine was given ≥14 days before enrollment. We used unconditional logistic regression to calculate odds ratios and calculated 2-dose and 1-dose vaccine effectiveness (VE) as (1 − odds ratio) * 100.
Results:
We included 129 (19%) positive cases and 543 (81%) negative controls. Among cases, 77 (60%) were positive for equine-like G3P[8]. Two doses of rotavirus vaccine were 66% (95% CI: 44, 80) effective against hospitalizations due to any strain of rotavirus and 64% (95% CI: 33, 81) effective against hospitalizations due to the equine-like G3P[8] genotype.
Conclusions:
These findings are comparable to other countries in the Americas region. To the best of our knowledge, this is the first VE estimate both against the equine-like G3P[8] genotype and from a Caribbean country. Overall, these results support rotavirus vaccine use and demonstrate the importance of complete vaccination.
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Pubmed ID:34187708
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Pubmed Central ID:PMC8474148
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Volume:39
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Issue:32
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