Predictors of Nonseroconversion after SARS-CoV-2 Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Liu, Weimin ; Russell, Ronnie M. ; Bibollet-Ruche, Frederic ; Skelly, Ashwin N. ; Sherrill-Mix, Scott ; Freeman, Drew A. ; Stoltz, Regina ; Lindemuth, Emily ; Lee, Fang-Hua ; Sterrett, Sarah ; Bar, Katharine J. ; Erdmann, Nathaniel ; Gouma, Sigrid ; Hensley, Scott E. ; Ketas, Thomas ; Cupo, Albert ; Cruz Portillo, Victor M. ; Moore, John P. ; Bieniasz, Paul D. ; Hatziioannou, Theodora ; Massey, Greer ; Minyard, Mary-Beth ; Saag, Michael S. ; Davis, Randall S. ; Shaw, George M. ; Britt, William J. ; Leal, Sixto M. ; Goepfert, Paul ; Hahn, Beatrice H.
• Description:
  Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.
• Subjects:
  Antibody Formation Coronavirus Infections Covid-19 Covid-19 Serological Testing Humans Nasopharynx Sars-Cov-2 Seroconversion
• Source:
  Emerg Infect Dis. 27(9):2454-2458
• Pubmed ID:
  34193339
• Pubmed Central ID:
  PMC8386781
• Document Type:
  Journal Article
• Funding:
  R37 AI150590/AI/NIAID NIH HHSUnited States/ ; T32 GM007170/GM/NIGMS NIH HHSUnited States/ ; R01 AI110553/AI/NIAID NIH HHSUnited States/ ; U19 AI082630/AI/NIAID NIH HHSUnited States/ ; R01 AI050529/AI/NIAID NIH HHSUnited States/ ; P01 AI110657/AI/NIAID NIH HHSUnited States/ ; P30 AI045008/AI/NIAID NIH HHSUnited States/ ; R01 AI036082/AI/NIAID NIH HHSUnited States/
• Volume:
  27
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1327c26805ffff9d54d37904a8adc0e8418d40249fa356f5a6a9b4e4010c8bdd
• Download URL:
  https://stacks.cdc.gov/view/cdc/109722/cdc_109722_DS1.pdf
• File Type:
  [PDF - 1.39 MB ]