Newborn screening for congenital hypothyroidism and congenital adrenal hyperplasia: the balance of benefits and costs of a public health success
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Newborn screening for congenital hypothyroidism and congenital adrenal hyperplasia: the balance of benefits and costs of a public health success

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English

Details:

  • Alternative Title:
    Med Sci (Paris)
  • Personal Author:
  • Description:
    Newborn screening is an important public health program and a triumph of preventive medicine. Economic analyses show that the benefits of newborn screening clearly outweigh the costs for certain diseases, but not necessarily for other ones. This is due to the great diversity of the natural history of the diseases detected, to the fact that each of these diseases considered individually is rare, and to differences in the effectiveness of interventions. In addition, the benefit-cost ratio of screening for a particular disorder may differ between countries, specifically between high-income and low- and middle-income countries. The burden of a disorder may also be alleviated by increased clinical awareness and effective clinical services, even in the absence of newborn screening. In this article, we focus on economic analyses of newborn screening for primary congenital hypothyroidism, which has been in place in high-income countries for roughly 40 years, and for classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Screening for the latter is not yet universal, even in high-income countries, although the lack of universal implementation may reflect factors other than economic considerations.
  • Subjects:
  • Source:
  • Pubmed ID:
    34003099
  • Pubmed Central ID:
    PMC8387970
  • Document Type:
  • Funding:
  • Volume:
    37
  • Issue:
    5
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