Early-onset colorectal cancer risk extends to second- and third-degree relatives

Details

• Alternative Title:
  Cancer Epidemiol
• Personal Author:
  Ochs-Balcom, Heather M. ; Kanth, Priyanka ; Cannon-Albright, Lisa A.
• Description:
  Introduction.
  
  Family history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown.
  
  Methods:
  
  We estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database.
  
  Results:
  
  We observed elevated risks beyond RR=2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively.
  
  Discussion:
  
  Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.
  
  
• Subjects:
  Article
• Source:
  Cancer Epidemiol. 73:101973
• Pubmed ID:
  34198235
• Pubmed Central ID:
  PMC8316419
• Document Type:
  Journal Article
• Funding:
  HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; P30 CA042014/CA/NCI NIH HHSUnited States/ ; HHSN261201100016I/CA/NCI NIH HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  73
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1ce61ed5a4f47eaa866774136dcb105b570ec58829562fe7b25baf2a9b58a0fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/108859/cdc_108859_DS1.pdf
• File Type:
  [PDF - 47.67 KB ]