Effects of Patient Characteristics on Diagnostic Performance of Self-Collected Samples for SARS-CoV-2 Testing

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Smith-Jeffcoat, Sarah E. ; Koh, Mitsuki ; Hoffman, Adam ; Rebolledo, Paulina A. ; Schechter, Marcos C. ; Miller, Halie K. ; Sleweon, Sadia ; Rossetti, Rebecca ; Kasinathan, Vyjayanti ; Shragai, Talya ; O’Laughlin, Kevin ; Espinosa, Catherine C. ; Khalil, George M. ; Adeyemo, AdeSubomi O. ; Moorman, Anne ; Bauman, Brenda L. ; Joseph, Kahaliah ; O’Hegarty, Michelle ; Kamal, Nazia ; Atallah, Hany ; Moore, Brooks L. ; Bohannon, Caitlin D. ; Bankamp, Bettina ; Hartloge, Claire ; Bowen, Michael D. ; Paulick, Ashley ; Gargis, Amy S. ; Elkins, Christopher ; Stewart, Rebekah J. ; da Silva, Juliana ; Biedron, Caitlin ; Tate, Jacqueline E. ; Wang, Yun F. ; Kirking, Hannah L.
• Corporate Authors:
  CDC COVID- ; Response Team1
• Description:
  We evaluated the performance of self-collected anterior nasal swab (ANS) and saliva samples compared with healthcare worker-collected nasopharyngeal swab specimens used to test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used the same PCR diagnostic panel to test all self-collected and healthcare worker-collected samples from participants at a public hospital in Atlanta, Georgia, USA. Among 1,076 participants, 51.9% were men, 57.1% were >50 years of age, 81.2% were Black (non-Hispanic), and 74.9% reported >1 chronic medical condition. In total, 8.0% tested positive for SARS-CoV-2. Compared with nasopharyngeal swab samples, ANS samples had a sensitivity of 59% and saliva samples a sensitivity of 68%. Among participants tested 3-7 days after symptom onset, ANS samples had a sensitivity of 80% and saliva samples a sensitivity of 85%. Sensitivity varied by specimen type and patient characteristics. These findings can help physicians interpret PCR results for SARS-CoV-2.
• Subjects:
  Aged, 80 And Over Coronavirus Infections/Diagnosisi Covid-19 Testing Covid-19/Diagnosisi Humans Male Nasopharynx Saliva Sars-Cov-2 Specimen Handling
• Source:
  Emerg Infect Dis. 27(8):2081-2089
• Pubmed ID:
  34286681
• Pubmed Central ID:
  PMC8314823
• Document Type:
  Journal Article
• Place as Subject:
  Atlanta, GA
• Location:
  North America
• Volume:
  27
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7ff790dff25c72788a798b3cbebdb48fc1660b5e8414fdd91d621652b5b756ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/108806/cdc_108806_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]