Details:

Alternative Title:
PLoS One
Personal Author:
Shi, GuoQing ; He, Jun ; Shen, Tao ; Fontaine, Robert E. ; Yang, Lin ; ... More +
Shi, GuoQing ; He, Jun ; Shen, Tao ; Fontaine, Robert E. ; Yang, Lin ; Zhou, ZhongYu ; Gao, Hong ; Xu, YanFeng ; Qin, Chuan ; Yang, ZhuLiang ; Liu, JiKai ; Huang, WenLi ; Zeng, Guang Less -
Description:
Background

Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice.

Methods

We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from the environs of a village that had SUD. We randomly allocated mice into treatment groups and administered mushroom extracts at doses ranging from 500 to 3500 mg/kg and water (control) via a gavage needle. We observed mice for mortality for 7 days after a 3500 mg/kg dose and for 24 hours after doses from 500 to 3000 mg/kg. We determined biochemical markers from serum two hours after a 2000 mg/kg dose.

Results

Ten mice fed T. venenata extract (3500 mg/kg) died by five hours whereas all control mice (L. vinaceoavellanea extract and water) survived the seven-day observation period. All mice died by five hours after exposure to single doses of T. venenata extract ranging from 1500 to 3000 mg/kg, while the four mice exposed to a 500 mg/kg dose all survived. Mice fed 2000 mg/kg of T. venenata extract developed profound hypoglycemia (median  = 0.66 mmol/L) two hours after exposure.

Discussion

Hypoglycemia and death within hours of exposure, a pattern unique among mushroom toxicity, characterize T. venenata poisoning.


Subject:
[+]
Agaricales
Animals
Female
Hypoglycemia
Male
Medicine
Mice
Mushroom Poisoning
Research Article

Source:
PLoS One. 2012; 7(6).
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:269a4c472118eada7f353d7d41a180d666b13d2c82ff094bd2c1e016414db5ea
File Type:

Supporting Files

• 	license.txt	txt
  	pone.0038712.nxml	txt
  	pone.0038712.t001.gif	gif
  	pone.0038712.t001.jpg	jpeg
  	pone.0038712.t002.gif	gif
  	pone.0038712.t002.jpg	jpeg

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