Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Soumana, Illiassou Hamidou ; Linz, Bodo ; Dewan, Kalyan K. ; Sarr, Demba ; Gestal, Monica C. ; ... More +
Soumana, Illiassou Hamidou ; Linz, Bodo ; Dewan, Kalyan K. ; Sarr, Demba ; Gestal, Monica C. ; Howard, Laura K. ; Caulfield, Amanda D. ; Rada, Balázs ; Harvill, Eric T. Less -
Description:
Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization and growth in the upper respiratory tract. We inoculated only the nasopharynx of mice to explore the course of infection in a more natural exposure model. Nasopharyngeal colonization resulted in robust growth in the upper respiratory tract but elicited little immune response, enabling prolonged and persistent infection. Immunization with human acellular pertussis vaccine, which prevents severe lung infections in the conventional pneumonic infection model, had little effect on nasopharyngeal colonization. Our infection model revealed that B. pertussis can efficiently colonize the mouse nasopharynx, grow and spread within and between respiratory organs, evade robust host immunity, and persist for months. This experimental approach can measure aspects of the infection processes not observed in the conventional pneumonic infection model.
Subject:
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Animals
Bordetella Infections
Immune Evasion
Mice
Nasopharynx
Pertussis Vaccine
Whooping Cough

Source:
Emerg Infect Dis. 27(8):2107-2116
Pubmed ID:
34286682
Pubmed Central ID:
PMC8314809
Document Type:
Journal Article
Funding:
R01 GM113681/GM/NIGMS NIH HHSUnited States/ ; R21 AI142678/AI/NIAID NIH HHSUnited States/ ; NH/NIH HHSUnited States/
R01 GM113681/GM/NIGMS NIH HHSUnited States/ ; R21 AI142678/AI/NIAID NIH HHSUnited States/ ; NH/NIH HHSUnited States/ Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6eff6f8352dbfd5db920a0662672669c869acc3954645f366ea26dc994e9f231
File Type:

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