Economic assessments of the burden of congenital cytomegalovirus infection and the cost-effectiveness of prevention strategies

Details

• Alternative Title:
  Semin Perinatol
• Personal Author:
  Grosse, Scott D. ; Dollard, Sheila C. ; Ortega-Sanchez, Ismael R.
• Description:
  Objective:
  
  This is a critical review of published economic analyses on congenital cytomegalovirus infection and strategies for its detection and prevention.
  
  Findings:
  
  The review identified four cost-of-illness studies and nine cost-effectiveness analyses: three of vaccination of young women, two of prenatal screening, and four of newborn screening. All reported either large economic costs or favorable cost-effectiveness of interventions. However, sensitivity analyses did not address some of the most critical assumptions.
  
  Conclusions:
  
  Reviewed economic analyses overattributed certain adverse long-term outcomes to congenital cytomegalovirus infection, while other long-term costs were not included. Overall, limited conceptual frameworks, unrepresentative data sources, and unsupported or inadequately documented assumptions regarding outcomes and costs hinder the ability of policymakers to draw conclusions. A major challenge is the limited information on long-term outcomes and costs for representative cohorts of individuals with congenital cytomegalovirus, which further research could helpfully address.
  
  
• Subjects:
  Cost-Benefit Analysis Cytomegalovirus Infections Female Humans Infant, Newborn Neonatal Screening
• Keywords:
  Congenital Cytomegalovirus Cost-effectiveness Cost Of Illness Economic Evaluation
• Source:
  Semin Perinatol. 45(3):151393
• Pubmed ID:
  33551180
• Pubmed Central ID:
  PMC8335728
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  45
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3d6544f38a08ead17bffe2e285012575756983b31e025e3f23e5db731d72d4ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/108716/cdc_108716_DS1.pdf
• File Type:
  [PDF - 406.95 KB ]