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Economic assessments of the burden of congenital cytomegalovirus infection and the cost-effectiveness of prevention strategies
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4 2021
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Source: Semin Perinatol. 45(3):151393
[PDF-406.95 KB]
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Alternative Title:Semin Perinatol
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Description:Objective:
This is a critical review of published economic analyses on congenital cytomegalovirus infection and strategies for its detection and prevention.
Findings:
The review identified four cost-of-illness studies and nine cost-effectiveness analyses: three of vaccination of young women, two of prenatal screening, and four of newborn screening. All reported either large economic costs or favorable cost-effectiveness of interventions. However, sensitivity analyses did not address some of the most critical assumptions.
Conclusions:
Reviewed economic analyses overattributed certain adverse long-term outcomes to congenital cytomegalovirus infection, while other long-term costs were not included. Overall, limited conceptual frameworks, unrepresentative data sources, and unsupported or inadequately documented assumptions regarding outcomes and costs hinder the ability of policymakers to draw conclusions. A major challenge is the limited information on long-term outcomes and costs for representative cohorts of individuals with congenital cytomegalovirus, which further research could helpfully address.
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Pubmed ID:33551180
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Pubmed Central ID:PMC8335728
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