Economic assessments of the burden of congenital cytomegalovirus infection and the cost-effectiveness of prevention strategies
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Economic assessments of the burden of congenital cytomegalovirus infection and the cost-effectiveness of prevention strategies

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  • English

  • Details:

    • Alternative Title:
      Semin Perinatol
    • Description:
      Objective: This is a critical review of published economic analyses on congenital cytomegalovirus infection and strategies for its detection and prevention. Findings: The review identified four cost-of-illness studies and nine cost-effectiveness analyses: three of vaccination of young women, two of prenatal screening, and four of newborn screening. All reported either large economic costs or favorable cost-effectiveness of interventions. However, sensitivity analyses did not address some of the most critical assumptions. Conclusions: Reviewed economic analyses overattributed certain adverse long-term outcomes to congenital cytomegalovirus infection, while other long-term costs were not included. Overall, limited conceptual frameworks, unrepresentative data sources, and unsupported or inadequately documented assumptions regarding outcomes and costs hinder the ability of policymakers to draw conclusions. A major challenge is the limited information on long-term outcomes and costs for representative cohorts of individuals with congenital cytomegalovirus, which further research could helpfully address.
    • Source:
      Semin Perinatol. 45(3):151393
    • Pubmed ID:
      33551180
    • Pubmed Central ID:
      PMC8335728
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