IL-15 increases the percentage of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine

Details

• Alternative Title:
  Cell Mol Immunol
• Personal Author:
  Li, Shirui ; Qi, Xiangrong ; Gao, Yingying ; Hao, Yanling ; Cui, Lianxian ; Ruan, Li ; He, Wei
• Description:
  Several studies have suggested that interleukin (IL)-15 is a promising adjuvant that promotes cellular immunity when administered with human immunodeficiency virus (HIV) vaccine. Here we evaluated the effect of IL-15 plasmid on HIV-specific immune responses, especially cellular immunity, in eight rhesus monkeys. These monkeys were immunized three times with HIV DNA vaccine with or without IL-15 plasmid and boosted with recombinant Tiantan strain vaccinia virus-based HIV vaccine (rTV) 22 weeks after the first immunization. Although we did not detect any significant differences in the HIV-specific CD8(+) T-cell response between monkeys with IL-15 coimmunization and monkeys with HIV vaccine alone, our results showed that the frequency of effector CD8(+) memory T cells in the peripheral blood was significantly higher in monkeys with IL-15 coimmunization than those with HIV vaccine alone at almost all of the time points examined. Furthermore, the titers of anti-HIV antibodies were higher in Group T than those in Group C after rTV boosting. These findings in rhesus monkeys suggest that IL-15 may be useful as a cytokine adjuvant for HIV vaccine.
• Subjects:
  • AIDS Vaccines
  • Animals
  • CD8-Positive T-Lymphocytes
  • Female
  • HIV Antibodies
  • Immunity, Humoral
  • Immunization
  • Immunologic Memory
  • Interleukin-15
  • Macaca mulatta
  More +
• Source:
  Cell Mol Immunol. 7(6):491-494.
• Document Type:
  Journal Article
• Volume:
  7
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/10868/cdc_10868_DS1.pdf
• File Type:
  [PDF - 449.63 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:74a3508ce4cd26ad5305f5484f7e0a533b88c6452d49afd239a9c762bec40c6e