Details:

Alternative Title:
Fertil Steril
Personal Author:
Crawford, Sara ; Boulet, Sheree L. ; Kawwass, Jennifer F. ; Jamieson, Denise J. ; Kissin, Dmitry M.
Crawford, Sara ; Boulet, Sheree L. ; Kawwass, Jennifer F. ; Jamieson, Denise J. ; Kissin, Dmitry M. Less -
Description:
Objective

To compare characteristics, explore predictors, and compare assisted reproductive technology (ART) cycle, transfer, and pregnancy outcomes of autologous and donor cryopreserved oocyte cycles with fresh oocyte cycles.

Design

Retrospective cohort study from the National ART Surveillance System.

Setting

Fertility treatment centers.

Patient(s)

Fresh embryo cycles initiated in 2013 utilizing embryos created with fresh and cryopreserved, autologous and donor oocytes.

Intervention(s)

Cryopreservation of oocytes versus fresh.

Main Outcomes Measure(s)

Cancellation, implantation, pregnancy, miscarriage, and live birth rates per cycle, transfer, and/or pregnancy.

Result(s)

There was no evidence of differences in cancellation, implantation, pregnancy, miscarriage, or live birth rates between autologous fresh and cryopreserved oocyte cycles. Donor cryopreserved oocyte cycles had a decreased risk of cancellation before transfer (adjusted risk ratio [aRR] 0.74, 95% confidence interval [CI] 0.57–0.96) as well as decreased likelihood of pregnancy (aRR 0.88, 95% CI 0.81–0.95) and live birth (aRR 0.87, 95% CI 0.80–0.95); however, there was no evidence of differences in implantation, pregnancy, or live birth rates when cycles were restricted to those proceeding to transfer. Donor cryopreserved oocyte cycles proceeding to pregnancy had a decreased risk of miscarriage (aRR 0.75, 95% CI 0.58–0.97) and higher live birth rate (aRR 1.05, 95% CI 1.01–1.09) with the transfer of one embryo, but higher miscarriage rate (aRR 1.28, 95% CI 1.07–1.54) and lower live birth rate (aRR 0.95, 95% CI 0.92–0.99) with the transfer of two or more.

Conclusion(s)

There was no evidence of differences in ART outcomes between autologous fresh and cryopreserved oocyte cycles. There was evidence of differences in per-cycle and per-pregnancy outcomes between donor cryopreserved and fresh oocyte cycles, but not in per-transfer outcomes.


Subject:
[+]
Abortion, Spontaneous
Adult
Chi-Square Distribution
Cryopreservation
Embryo Implantation
Embryo Transfer
Female
Fertility
Fertilization In Vitro
Humans
Infertility
Live Birth
Odds Ratio
Oocyte Donation
Oocyte Retrieval
Ovulation Induction
Pregnancy
Pregnancy Rate
Retrospective Studies
Risk Assessment
Risk Factors
Treatment Outcome

Source:
Fertil Steril. 107(1):110-118.
Pubmed ID:
27842997
Pubmed Central ID:
PMC5590714
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:36a9fee6ef9c9084b510ba75dd1745ef33bd7f73564f2570d71630f6d8be8e8e
File Type:

Supporting Files

• nihms895398.nxml

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